PDF(Pubmed)
Abstract：
BACKGROUND: Borna disease virus 1 (BoDV-1) causes rare human infections within endemic regions in southern and eastern Germany. The infections reported to date have been linked to severe courses of encephalitis with high mortality and mostly irreversible symptoms. Whether BoDV-1 could act as a trigger for other neurological conditions, is, however, incompletely understood.
OBJECTIVE: In this study, we addressed the question of whether the presentation of a clinically isolated syndrome (CIS) or of multiple sclerosis (MS) might be associated with a milder course of BoDV-1 infections. Serum samples of 100 patients with CIS or MS diagnosed at a tertiary neurological care center within an endemic region in southern Germany and of 50 control patients suffering from headache were retrospectively tested for BoDV-1 infections.
RESULTS: In none of the tested sera, confirmed positive results of anti-BoDV-1-IgG antibodies were retrieved. Our results support the conclusion that human BoDV-1 infections primarily lead to severe encephalitis with high mortality.
OBJECTIVE: In this study, we addressed the question of whether the presentation of a clinically isolated syndrome (CIS) or of multiple sclerosis (MS) might be associated with a milder course of BoDV-1 infections. Serum samples of 100 patients with CIS or MS diagnosed at a tertiary neurological care center within an endemic region in southern Germany and of 50 control patients suffering from headache were retrospectively tested for BoDV-1 infections.
RESULTS: In none of the tested sera, confirmed positive results of anti-BoDV-1-IgG antibodies were retrieved. Our results support the conclusion that human BoDV-1 infections primarily lead to severe encephalitis with high mortality.
摘要：
背景：博尔纳病病毒1（BoDV-1）在德国南部和东部的流行地区引起罕见的人类感染。迄今报告的感染与脑炎的严重病程有关，死亡率高，症状大多不可逆。BoDV-1是否可以作为其他神经系统疾病的触发因素，是，然而,不完全理解。
目的：在本研究中，我们解决了以下问题:临床孤立综合征(CIS)或多发性硬化(MS)的表现是否与BoDV-1感染的轻度病程有关.在德国南部流行地区的三级神经护理中心诊断出的100名CIS或MS患者的血清样本以及50名患有头痛的对照患者的BoDV-1感染进行了回顾性测试。
结果：在没有测试血清中，已确认抗BoDV-1-IgG抗体阳性结果。我们的结果支持以下结论：人类BoDV-1感染主要导致高死亡率的严重脑炎。
目的：在本研究中，我们解决了以下问题:临床孤立综合征(CIS)或多发性硬化(MS)的表现是否与BoDV-1感染的轻度病程有关.在德国南部流行地区的三级神经护理中心诊断出的100名CIS或MS患者的血清样本以及50名患有头痛的对照患者的BoDV-1感染进行了回顾性测试。
结果：在没有测试血清中，已确认抗BoDV-1-IgG抗体阳性结果。我们的结果支持以下结论：人类BoDV-1感染主要导致高死亡率的严重脑炎。
