关键词: Myelin oligodendrocyte glycoprotein Opsoclonus myoclonus ataxia syndrome Parainfectious disease SARS-CoV-2

Mesh : Humans Male Middle Aged Opsoclonus-Myoclonus Syndrome / etiology COVID-19 / complications Myelin-Oligodendrocyte Glycoprotein / immunology SARS-CoV-2

来  源:   DOI:10.1007/s12311-023-01610-9

Abstract:
Opsoclonus-myoclonus syndrome (OMS) as a rare neurological encephalopathic entity associated with non-specific infections or cancer processes has been repeatedly described in the setting of SARS-CoV-2 infection. We report a case of a 53-year-old man with SARS-CoV-2 infection, who developed clinical features of opsoclonus-myoclonus ataxia syndrome including cognitive impairments with a prolonged course of disease. Of particular note, cerebrospinal fluid (CSF) analysis revealed the production of myelin oligodendrocyte glycoprotein (MOG) antibodies, suggesting an underlying neuroimmunological mechanism associated with infection with the novel SARS-CoV-2 virus.
摘要:
在SARS-CoV-2感染的背景下,已反复描述了作为与非特异性感染或癌症过程相关的罕见神经系统脑病综合征(OMS)。我们报告了一例53岁的SARS-CoV-2感染患者,他出现了眼阵挛性-肌阵挛性共济失调综合征的临床特征,包括病程延长的认知障碍。特别值得注意的是,脑脊液(CSF)分析显示髓鞘少突胶质细胞糖蛋白(MOG)抗体的产生,提示与新型SARS-CoV-2病毒感染相关的潜在神经免疫机制。
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