关键词: Chronic inflammatory demyelinating polyradiculoneuropathy anti-sulfatide antibody case report cranial nerve ophthalmoplegia peripheral nervous system

Mesh : Humans Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis drug therapy Retrospective Studies Immunoglobulins, Intravenous / therapeutic use Ophthalmoplegia Immunoglobulin M / therapeutic use

来  源:   DOI:10.1177/03000605231193575   PDF(Pubmed)

Abstract:
BACKGROUND: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a heterogeneous group of chronic immune-mediated polyradiculoneuropathies. The clinical presentation of CIDP is mainly characterized by a classic peripheral demyelinating sensory-motor type and persists for a minimum of 2 months. However, CIDP may also present with atypical symptoms.Case presentation: This report presents the case of a patient with CIDP with ophthalmoplegia and anti-sulfatide IgM antibodies. Maintenance intravenous immunoglobulin and glucocorticoid therapies were administered to the patient in accordance with the clinical, laboratory, and electrophysiological findings, which were indicative of CIDP. The treatment partially improved the symptoms, and no recurrence was detected throughout the 3-month monitoring phase.
CONCLUSIONS: This study combines a retrospective analysis and a literature review to explore the possible mechanism of CIDP.
摘要:
背景:慢性炎症性脱髓鞘性多发性神经根神经病(CIDP)是一组异质性的慢性免疫介导的多发性神经根神经病。CIDP的临床表现主要以经典的外周脱髓鞘感觉运动类型为特征,并持续至少2个月。然而,CIDP也可能表现为非典型症状。病例介绍:本报告介绍了患有眼肌麻痹和抗硫酸盐IgM抗体的CIDP患者的病例。根据临床对患者进行维持静脉注射免疫球蛋白和糖皮质激素治疗,实验室,和电生理发现,这表明CIDP。治疗部分改善了症状,在整个3个月监测阶段均未发现复发.
结论:本研究采用回顾性分析和文献综述相结合的方法探讨CI-DP的可能机制。
公众号