PDF(Pubmed)
Abstract：
BACKGROUND: Cancer survivors are less likely than comparably aged individuals without a cancer history to develop Alzheimer\'s disease and related dementias (ADRD).
METHODS: In the UK Biobank, we investigated associations between cancer history and five structural magnetic resonance imaging (MRI) markers for ADRD risk, using linear mixed-effects models to assess differences in mean values and quantile regression to examine whether associations varied across the distribution of MRI markers.
RESULTS: Cancer history was associated with smaller mean hippocampal volume (b = -19 mm3 , 95% CI = -36, -1) and lower mean cortical thickness in the Alzheimer\'s disease signature region (b = -0.004 mm, 95% CI = -0.007, -0.000). Quantile regressions indicated individuals most vulnerable to ADRD were more affected by cancer history.
CONCLUSIONS: Some brain MRI markers associated with ADRD risk were elevated in adults with a history of cancer. The magnitude of the adverse associations varied across quantiles of neuroimaging markers, and the pattern suggests possible harmful associations for individuals already at high ADRD risk.
CONCLUSIONS: We found no evidence of an inverse association between cancer history and ADRD-related neurodegeneration. Cancer history was associated with smaller mean hippocampal volume and lower mean cortical thickness in the Alzheimer\'s disease signature region. Quantile regressions indicated individuals most vulnerable to ADRD were more affected by cancer history.
METHODS: In the UK Biobank, we investigated associations between cancer history and five structural magnetic resonance imaging (MRI) markers for ADRD risk, using linear mixed-effects models to assess differences in mean values and quantile regression to examine whether associations varied across the distribution of MRI markers.
RESULTS: Cancer history was associated with smaller mean hippocampal volume (b = -19 mm3 , 95% CI = -36, -1) and lower mean cortical thickness in the Alzheimer\'s disease signature region (b = -0.004 mm, 95% CI = -0.007, -0.000). Quantile regressions indicated individuals most vulnerable to ADRD were more affected by cancer history.
CONCLUSIONS: Some brain MRI markers associated with ADRD risk were elevated in adults with a history of cancer. The magnitude of the adverse associations varied across quantiles of neuroimaging markers, and the pattern suggests possible harmful associations for individuals already at high ADRD risk.
CONCLUSIONS: We found no evidence of an inverse association between cancer history and ADRD-related neurodegeneration. Cancer history was associated with smaller mean hippocampal volume and lower mean cortical thickness in the Alzheimer\'s disease signature region. Quantile regressions indicated individuals most vulnerable to ADRD were more affected by cancer history.
摘要：
背景：癌症幸存者比没有癌症病史的年龄相当大的个体更不可能发生阿尔茨海默病和相关痴呆（ADRD）。
方法：在英国生物银行，我们调查了癌症病史与ADRD风险的五种结构磁共振成像（MRI）标记之间的关联，使用线性混合效应模型来评估平均值的差异,并使用分位数回归来检查MRI标记物分布之间的关联是否不同.
结果：癌症病史与较小的平均海马体积相关（b=-19mm3，95%CI=-36，-1）和阿尔茨海默病特征区域的较低平均皮质厚度（b=-0.004mm，95%CI=-0.007，-0.000）。分位数回归表明，最容易受到ADRD影响的个体受癌症史的影响更大。
结论：一些与ADRD风险相关的脑MRI标记在有癌症史的成年人中升高。不良关联的程度因神经影像学标记的分位数而异，并且该模式提示已经处于高ADRD风险的个体可能存在有害关联。
结论：我们没有发现癌症病史与ADRD相关的神经变性呈负相关的证据。癌症病史与阿尔茨海默病特征区域较小的平均海马体积和较低的平均皮质厚度相关。分位数回归表明，最容易受到ADRD影响的个体受癌症史的影响更大。
方法：在英国生物银行，我们调查了癌症病史与ADRD风险的五种结构磁共振成像（MRI）标记之间的关联，使用线性混合效应模型来评估平均值的差异,并使用分位数回归来检查MRI标记物分布之间的关联是否不同.
结果：癌症病史与较小的平均海马体积相关（b=-19mm3，95%CI=-36，-1）和阿尔茨海默病特征区域的较低平均皮质厚度（b=-0.004mm，95%CI=-0.007，-0.000）。分位数回归表明，最容易受到ADRD影响的个体受癌症史的影响更大。
结论：一些与ADRD风险相关的脑MRI标记在有癌症史的成年人中升高。不良关联的程度因神经影像学标记的分位数而异，并且该模式提示已经处于高ADRD风险的个体可能存在有害关联。
结论：我们没有发现癌症病史与ADRD相关的神经变性呈负相关的证据。癌症病史与阿尔茨海默病特征区域较小的平均海马体积和较低的平均皮质厚度相关。分位数回归表明，最容易受到ADRD影响的个体受癌症史的影响更大。
