UNASSIGNED: In this article, we discuss the use of dupilumab for adult patients with prurigo nodularis. Dupilumab is a biologic that inhibits Th2-mediated inflammation and has been successfully used to treat a variety of dermatologic disorders. Dupilumab has revolutionized the management of PN, with recent clinical trials showing its efficacy in treating both pruritus and prurigo nodules, as well as improving quality of life. It has a favorable safety profile and is well tolerated. Other novel treatments are also currently under investigation for the treatment of PN, with early studies reporting promising results.
UNASSIGNED: Dupilumab is becoming the drug of choice for the treatment of PN and may also be effective in treating patients with systemic underlying causes of their PN, although more studies are needed to assess this. Trials evaluating the long-term efficacy and durability of dupilumab in PN are also of interest.
■在本文中,我们讨论了dupilumab在结节性痒疹成年患者中的应用.Dupilumab是一种抑制Th2介导的炎症的生物制剂,已成功用于治疗多种皮肤病。Dupilumab彻底改变了PN的管理,最近的临床试验显示其治疗瘙痒和瘙痒结节的疗效,以及提高生活质量。它具有良好的安全性和耐受性。其他新的治疗方法目前也在研究中,用于治疗PN。早期研究报告了有希望的结果。
■Dupilumab正在成为治疗PN的首选药物,也可能有效治疗患有全身性PN的潜在原因的患者。尽管需要更多的研究来评估这一点。评估dupilumab在PN中的长期疗效和耐久性的试验也是感兴趣的。