PDF(Pubmed)
Abstract：
In the context of coronavirus disease 2019 (COVID-19), laboratory medicine has played a crucial role in both diagnosis and severity assessment. Although the importance of baseline laboratory findings has been extensively reported, data regarding their evolution over the clinical course are limited. The aim of the present narrative review was to provide the dynamic changes of the routine laboratory variables reported in patients with severe COVID-19 over the course of their critical illness. A search was made of the literature for articles providing data on the time-course of routine laboratory tests in patients with severe COVID-19 during their stay in the intensive care unit (ICU). White blood cell, neutrophil and lymphocyte counts, neutrophil to lymphocyte ratio, platelet counts, as well as D-dimer, fibrinogen, C-reactive protein, lactate dehydrogenase and serum albumin levels were selected as disease characteristics and routine laboratory parameters. A total of 25 research articles reporting dynamic trends in the aforementioned laboratory parameters over the clinical course of severe COVID-19 were identified. During the follow-up period provided by each study, the majority of the laboratory values remained persistently abnormal in both survivors and non-survivors. Furthermore, in the majority of studies, the temporal trends of laboratory values distinctly differentiated patients between survivors and non-survivors. In conclusion, there are distinct temporal trends in selected routine laboratory parameters between survivors and non-survivors with severe COVID-19 admitted to the ICU, indicating their importance in the prognosis of clinical outcome.
摘要：
在2019年冠状病毒病（COVID-19）的背景下，实验室医学在诊断和严重程度评估中起着至关重要的作用.尽管已经广泛报道了基线实验室发现的重要性，关于它们在临床过程中的演变的数据是有限的.本叙述性综述的目的是提供重症COVID-19患者在其危重疾病过程中报告的常规实验室变量的动态变化。在文献中搜索了提供重症COVID-19患者在重症监护病房（ICU）期间常规实验室检查时间过程数据的文章。白细胞,中性粒细胞和淋巴细胞计数，中性粒细胞与淋巴细胞的比率，血小板计数,以及D-二聚体,纤维蛋白原，C反应蛋白,选择乳酸脱氢酶和血清白蛋白水平作为疾病特征和常规实验室指标。总共有25篇研究文章报告了上述实验室参数在重症COVID-19临床过程中的动态趋势。在每个研究提供的随访期间，在幸存者和非幸存者中,大部分实验室值持续异常.此外，在大多数研究中，实验室值的时间趋势在幸存者和非幸存者之间有明显的区别.总之,入住ICU的重度COVID-19的幸存者和非幸存者之间的选定常规实验室参数存在明显的时间趋势，表明它们在临床预后中的重要性。
