PDF(Pubmed)
Abstract：
Severe hypokalaemia causing rhabdomyolysis (RML) in primary aldosteronism (PA) is a rare entity, and only a few cases have been reported over the last four decades. This systematic review and case report aims to gather all published data regarding a hypokalaemic RML as presentation of PA in order to contribute to the early diagnosis of this extremely rare presentation. With the use of PubMed Central, EMBASE, and Google Scholar, a thorough internet-based search of the literature was conducted to identify articles and cases with RML secondary to hypokalaemia due to PA between June 1976 and July 2023. The case study concerns a 68-year-old male patient with hypokalaemic RML at presentation of PA. In the systematic review of the literature, 37 cases of RML secondary to hypokalaemia due to PA have been reported to date. In summary, the median age was 47.5 years, the male/female ratio was 17/21, all patients presented symptoms (weakness and/or myalgia), all the patients were hypertensive, and only four patients had complications with acute kidney injury (AKI). Although PA rarely presents with RML, it should be suspected when marked hypokalaemia and hypertension are also present. Early detection and management are essential to reduce the frequency of manifestations such as AKI.
摘要：
严重的低钾血症导致原发性醛固酮增多症（PA）的横纹肌溶解症（RML）是一种罕见的实体，在过去的四十年里，只有少数病例被报道。本系统综述和病例报告旨在收集所有已发表的有关低钾血症RML作为PA表现的数据，以有助于这种极为罕见的表现的早期诊断。随着PubMedCentral的使用，EMBASE,和谷歌学者，我们进行了一项基于互联网的全面文献检索,以确定1976年6月至2023年7月期间PA引起的低钾血症继发RML的文章和病例.该病例研究涉及一名68岁的男性患者，在出现PA时患有低钾性RML。在文献的系统回顾中，迄今为止，已报告了37例由于PA引起的低钾血症继发的RML。总之,中位年龄为47.5岁,男女比例为17/21，所有患者均出现症状（无力和/或肌痛），所有的病人都是高血压,只有4例患者出现急性肾损伤(AKI)并发症.虽然PA很少出现RML，当同时存在明显的低钾血症和高血压时，应怀疑。早期发现和管理对于减少AKI等表现的频率至关重要。
