PDF(Pubmed)
Abstract：
UNASSIGNED: A 3-year-old castrated male domestic shorthaired cat, with indoor-outdoor access, was presented for chronic, progressive multinodular to generalised subcutaneous nodules covering much of its body. Previous medical treatment with doxycycline had been unhelpful. Fine-needle aspiration of the nodules revealed intra- and extracellular multibacillary negative staining rods in pyogranulomatous inflammation. Bacterial culture and susceptibility studies isolated Mycobacterium intracellulare, with zimine as the drug of choice for treatment. Initial triple therapy with rifampicin, azithromycin and pradofloxacin was ineffective, and was changed to triple therapy with clofazimine, clarithromycin and doxycycline once drug susceptibility was known, which was given for 3 months, after which long-term therapy with clofazimine and clarithromycin was continued.
UNASSIGNED: Slow growing M intracellulare, a member of the Mycobacterium avium complex (MAC), has never been reported to cause disease in cats from Singapore and, by extension, Southeast Asia. The infection in this patient resulted in subcutaneous nodules, which started on the face, then spread to the feet and much of the rest of its body. This is in contrast to that commonly reported for infection with M avium, which is also a member of MAC, and may not only present with similar signs in cats, but also progress to systemic spread. Susceptibility studies suggest clofazimine as the drug of choice when treating this infection, and this case supports its use as empirical therapy for veterinarians treating this disease in this region while awaiting culture and sensitivity results.
UNASSIGNED: Slow growing M intracellulare, a member of the Mycobacterium avium complex (MAC), has never been reported to cause disease in cats from Singapore and, by extension, Southeast Asia. The infection in this patient resulted in subcutaneous nodules, which started on the face, then spread to the feet and much of the rest of its body. This is in contrast to that commonly reported for infection with M avium, which is also a member of MAC, and may not only present with similar signs in cats, but also progress to systemic spread. Susceptibility studies suggest clofazimine as the drug of choice when treating this infection, and this case supports its use as empirical therapy for veterinarians treating this disease in this region while awaiting culture and sensitivity results.
摘要：
■一只3岁阉割的雄性家养短毛猫，有室内-室外通道，被提出用于慢性，渐进的多结节到广泛的皮下结节覆盖其身体的大部分。以前使用多西环素的药物治疗无济于事。结节的细针抽吸显示脓性肉芽肿性炎症中的细胞内和细胞外多杆菌阴性染色棒。细菌培养和敏感性研究分离的分枝杆菌，以齐明作为治疗的首选药物。最初使用利福平三联疗法，阿奇霉素和普拉多沙星无效，改用氯法齐明三联疗法，克拉霉素和多西环素一旦药物敏感性已知，给了三个月，之后继续使用氯法齐明和克拉霉素的长期治疗。
■细胞内M生长缓慢，鸟分枝杆菌复合体（MAC）的成员，从未报道过在新加坡的猫中引起疾病，通过延伸,东南亚。这个病人的感染导致皮下结节,从脸上开始，然后扩散到脚和身体其他部分。这与通常报道的鸟分枝杆菌感染相反，也是MAC的成员，可能不仅在猫身上出现类似的症状，而且还进展到系统传播。药敏研究表明，氯法齐明作为治疗这种感染的首选药物，这种情况下支持使用它作为经验疗法的兽医治疗这种疾病在该地区，同时等待培养和敏感性结果。
■细胞内M生长缓慢，鸟分枝杆菌复合体（MAC）的成员，从未报道过在新加坡的猫中引起疾病，通过延伸,东南亚。这个病人的感染导致皮下结节,从脸上开始，然后扩散到脚和身体其他部分。这与通常报道的鸟分枝杆菌感染相反，也是MAC的成员，可能不仅在猫身上出现类似的症状，而且还进展到系统传播。药敏研究表明，氯法齐明作为治疗这种感染的首选药物，这种情况下支持使用它作为经验疗法的兽医治疗这种疾病在该地区，同时等待培养和敏感性结果。
