PDF(Pubmed)
Abstract：
UNASSIGNED: The hyalinizing trabecular tumor (HTT) is a rare benign neoplasm of the thyroid gland. This neoplasm has overlapping cytological features with Papillary Thyroid Carcinoma, Medullary Carcinoma and Follicular Neoplasm with Nuclear Features of Papillary Carcinoma. This can lead to misdiagnosis of malignancy in fine needle aspiration (FNA) cytology specimens with unnecessary total thyroidectomy. The aim of this study is to determine if there are some cytological features that could help us to suspect HTT on FNA specimens and avoid radical surgery.
UNASSIGNED: With this purpose we have collected 6 cases diagnosed of HTT in Hospital Clínico San Carlos of Madrid (Spain) in the last 10 years and reviewed the cytological specimens.
UNASSIGNED: We conclude that the presence of hyaline material in FNA specimens of HTT is a constant feature being a diagnostic clue. We must be cautious not to confuse it with dense colloid or amyloid material, the latter seen in Medullary Carcinoma. Papillary architecture and fibrovascular cores are not present in a HTT. Special stains as ki-67, calcitonin and Congo Red staining could help us in achieving the correct diagnosis.
UNASSIGNED: We feel the cytopathologists must be aware of the distinguishing features of this lesion, mainly the typical hyaline material to achieve a proper diagnosis and be able to reduce unnecessary aggressive management of these patients.
UNASSIGNED: With this purpose we have collected 6 cases diagnosed of HTT in Hospital Clínico San Carlos of Madrid (Spain) in the last 10 years and reviewed the cytological specimens.
UNASSIGNED: We conclude that the presence of hyaline material in FNA specimens of HTT is a constant feature being a diagnostic clue. We must be cautious not to confuse it with dense colloid or amyloid material, the latter seen in Medullary Carcinoma. Papillary architecture and fibrovascular cores are not present in a HTT. Special stains as ki-67, calcitonin and Congo Red staining could help us in achieving the correct diagnosis.
UNASSIGNED: We feel the cytopathologists must be aware of the distinguishing features of this lesion, mainly the typical hyaline material to achieve a proper diagnosis and be able to reduce unnecessary aggressive management of these patients.
摘要：
■透明小梁肿瘤（HTT）是一种罕见的甲状腺良性肿瘤。该肿瘤与甲状腺乳头状癌具有重叠的细胞学特征，髓样癌和具有乳头状癌核特征的滤泡性肿瘤。这可能导致细针穿刺（FNA）细胞学标本中恶性肿瘤的误诊，并进行不必要的甲状腺全切除术。这项研究的目的是确定是否有一些细胞学特征可以帮助我们怀疑FNA标本上的HTT并避免进行根治性手术。
■为此目的，我们收集了过去10年在马德里（西班牙）的ClínicoSanCarlos医院诊断为HTT的6例病例，并审查了细胞学标本。
■我们得出结论，HTT的FNA标本中透明物质的存在是诊断线索的恒定特征。我们必须谨慎，不要将其与致密的胶体或淀粉样物质混淆，后者见于髓样癌。在HTT中不存在乳头状结构和纤维血管核。特殊染色如ki-67，降钙素和刚果红染色可以帮助我们实现正确的诊断。
■我们认为细胞病理学家必须意识到这种病变的显着特征，主要是典型的透明材料，以实现正确的诊断，并能够减少这些患者不必要的积极管理。
■为此目的，我们收集了过去10年在马德里（西班牙）的ClínicoSanCarlos医院诊断为HTT的6例病例，并审查了细胞学标本。
■我们得出结论，HTT的FNA标本中透明物质的存在是诊断线索的恒定特征。我们必须谨慎，不要将其与致密的胶体或淀粉样物质混淆，后者见于髓样癌。在HTT中不存在乳头状结构和纤维血管核。特殊染色如ki-67，降钙素和刚果红染色可以帮助我们实现正确的诊断。
■我们认为细胞病理学家必须意识到这种病变的显着特征，主要是典型的透明材料，以实现正确的诊断，并能够减少这些患者不必要的积极管理。
