PDF(Pubmed)
Abstract：
In this paper, we outline how one might conduct a comprehensive ethical evaluation of human brain organoid transplantation in animals. Thus far, ethical concerns regarding this type of research have been assumed to be similar to those associated with other transplants of human cells in animals, and have therefore not received significant attention. The focus has been only on the welfare, moral status, or mental capacities of the host animal. However, the transplantation of human brain organoids introduces several new ethical issues. Many of these are related to uncertainty regarding whether or not brain organoids might be conscious. While these concerns might not be immediately relevant, they warrant closer scrutiny. We discuss how various ethical issues are relevant to different stages of human brain organoid transplantation and can guide the ethical evaluation of research. Our examination would broaden the horizons of the debate on the transplantation of brain organoids.
摘要：
在本文中,我们概述了如何对动物的人脑类器官移植进行全面的伦理评估。到目前为止,关于这类研究的伦理问题被认为与其他动物移植人类细胞的相关问题相似，因此并没有受到极大的关注。重点只放在福利上，道德地位,或宿主动物的心理能力。然而,人脑类器官的移植引入了几个新的伦理问题。其中许多与大脑类器官是否有意识的不确定性有关。虽然这些担忧可能并不立即相关，他们需要更仔细的审查。我们讨论了各种伦理问题如何与人脑类器官移植的不同阶段相关，并可以指导研究的伦理评估。我们的检查将拓宽有关脑类器官移植的辩论的视野。
