Abstract：
OBJECTIVE: Hypoxic-ischemic brain injury (HIBI) occurs when there is deficient oxygen supply and blood flow to the brain. HIBI can be precipitated by various factors including drug overdose. Brain regions that have high vulnerability to HIBI include the hippocampus and basal ganglia. Even when damage is limited to these two regions, research suggests that diffuse cognitive deficits and changes in behavior-emotional functioning can be observed.
METHODS: This case study presents on a 29-year-old female who sustained HIBI to the bilateral hippocampi and globus pallidus secondary to an opioid overdose which required a 3-day hospitalization. The patient was discharged from the hospital on suboxone therapy and completed outpatient interventions which included physical therapy as well as speech-language therapy with cognitive rehab. Although improvements in her functional status were noted, she reported having persisting difficulties with cognition in addition to post-injury behavioral-emotional changes. As such, she was referred for neuropsychological testing and the evaluation was completed 6 months after her hospitalization.
RESULTS: Testing showed prominent memory impairments along with deficits in language, visuospatial skills, executive functioning, and attention. On questionnaires, she endorsed having concerns for depression, attention, and executive functioning in daily life whereas her mother endorsed concerns for executive functioning.
CONCLUSIONS: The patient\'s neurobehavioral profile was consistent with broad ranging sequela that can be observed with HIBI. Recommendations included medication consultation for mood, compensatory cognitive strategies, and vocational rehab for individuals with neurological disabilities. Overall, this case study demonstrates the important role of neuropsychologists in the assessment and treatment of individuals recovering from HIBI.
METHODS: This case study presents on a 29-year-old female who sustained HIBI to the bilateral hippocampi and globus pallidus secondary to an opioid overdose which required a 3-day hospitalization. The patient was discharged from the hospital on suboxone therapy and completed outpatient interventions which included physical therapy as well as speech-language therapy with cognitive rehab. Although improvements in her functional status were noted, she reported having persisting difficulties with cognition in addition to post-injury behavioral-emotional changes. As such, she was referred for neuropsychological testing and the evaluation was completed 6 months after her hospitalization.
RESULTS: Testing showed prominent memory impairments along with deficits in language, visuospatial skills, executive functioning, and attention. On questionnaires, she endorsed having concerns for depression, attention, and executive functioning in daily life whereas her mother endorsed concerns for executive functioning.
CONCLUSIONS: The patient\'s neurobehavioral profile was consistent with broad ranging sequela that can be observed with HIBI. Recommendations included medication consultation for mood, compensatory cognitive strategies, and vocational rehab for individuals with neurological disabilities. Overall, this case study demonstrates the important role of neuropsychologists in the assessment and treatment of individuals recovering from HIBI.
摘要：
目的：缺氧缺血性脑损伤（HIBI）发生在氧气供应不足和大脑血流不足时。HIBI可通过包括药物过量在内的多种因素而沉淀。高度易患HIBI的脑区包括海马和基底神经节。即使损害仅限于这两个区域，研究表明，可以观察到弥漫性认知缺陷和行为情绪功能的变化。
方法：本案例研究涉及一名29岁女性，该女性因阿片类药物过量而导致双侧海马和苍白球持续HIBI，需要住院3天。患者接受suboxone治疗后出院，并完成了门诊干预措施，包括物理治疗以及言语语言治疗和认知康复。尽管注意到她的功能状态有所改善，她报告说，除了受伤后的行为情绪变化外，她还存在持续的认知困难。因此，她被转诊接受神经心理学测试,并在住院后6个月完成评估.
结果：测试显示明显的记忆障碍和语言障碍，视觉空间技能，执行功能，和注意。在问卷调查中，她赞同对抑郁症的担忧，注意,和日常生活中的执行功能，而她的母亲赞同对执行功能的担忧。
结论：患者的神经行为特征与HIBI可观察到的广泛后遗症一致。建议包括情绪的药物咨询，补偿性认知策略，和神经系统残疾人士的职业康复。总的来说,本案例研究证明了神经心理学家在评估和治疗HIBI康复患者中的重要作用.
方法：本案例研究涉及一名29岁女性，该女性因阿片类药物过量而导致双侧海马和苍白球持续HIBI，需要住院3天。患者接受suboxone治疗后出院，并完成了门诊干预措施，包括物理治疗以及言语语言治疗和认知康复。尽管注意到她的功能状态有所改善，她报告说，除了受伤后的行为情绪变化外，她还存在持续的认知困难。因此，她被转诊接受神经心理学测试,并在住院后6个月完成评估.
结果：测试显示明显的记忆障碍和语言障碍，视觉空间技能，执行功能，和注意。在问卷调查中，她赞同对抑郁症的担忧，注意,和日常生活中的执行功能，而她的母亲赞同对执行功能的担忧。
结论：患者的神经行为特征与HIBI可观察到的广泛后遗症一致。建议包括情绪的药物咨询，补偿性认知策略，和神经系统残疾人士的职业康复。总的来说,本案例研究证明了神经心理学家在评估和治疗HIBI康复患者中的重要作用.
