Abstract：
The PRR11 gene (Proline Rich 11) has been implicated in lung cancer; however, relationship between PRR11 and immune infiltration is not clearly understood. In this study, we used The Cancer Genome Atlas (TCGA) data to analyze the lung adenocarcinoma patients; PRR11 gene expression, clinicopathological findings, enrichment, and immune infiltration were also studied. PRR11 immune response expression assays in lung adenocarcinoma (LUAD) were performed using TIMER, and statistical analysis and visualization were conducted using R software. All data were verified using Gene Expression Profiling Interactive Analysis (GEPIA), and the Human Protein Atlas (HPA). We found that PRR11 was an important prognostic factor in patients with LUAD. PRR11 expression was correlated with tumor stage and progression. Gene Set Enrichment Analysis (GSEA) showed that PRR11 was enriched in the cell cycle regulatory pathways. Immune infiltration analysis revealed that the number of T helper 2 (Th2) cells increased when PRR11 was overexpressed. These results confirm the role of PRR11 as a prognostic marker of lung adenocarcinoma by controlling the cell cycle and influencing the immune system to facilitate lung cancer progression.
摘要：
PRR11基因（脯氨酸11）与肺癌有关；然而，PRR11与免疫浸润的关系尚不清楚。在这项研究中,我们使用癌症基因组图谱(TCGA)数据分析肺腺癌患者;PRR11基因表达,临床病理发现，富集,和免疫浸润也进行了研究。使用TIMER进行肺腺癌（LUAD）中PRR11免疫反应表达测定，利用R软件进行统计分析和可视化。所有数据均使用基因表达谱交互分析(GEPIA)进行验证，和人蛋白图谱(HPA)。我们发现PRR11是LUAD患者的重要预后因素。PRR11表达与肿瘤分期和进展相关。基因集富集分析(GSEA)显示PRR11富集在细胞周期调控途径中。免疫浸润分析显示，当PRR11过表达时，T辅助细胞2（Th2）细胞的数量增加。这些结果通过控制细胞周期和影响免疫系统以促进肺癌进展证实了PRR11作为肺腺癌预后标志物的作用。
