关键词: COVID-19 Case reports Reactive arthritis SARS-CoV-2

Mesh : Male Humans Adult Arthritis, Reactive / diagnosis drug therapy etiology COVID-19 / complications SARS-CoV-2 HLA-B27 Antigen

来  源:   DOI:10.1007/s00296-023-05480-6

Abstract:
Reactive arthritis (ReA) is a clinical condition typically triggered by extra-articular bacterial infections and often associated with the presence of HLA-B27. While ReA has traditionally been associated with gastrointestinal and genitourinary infections, its pathogenesis involves immune and inflammatory responses that lead to joint affections. The emergence of COVID-19, caused by SARS-CoV-2, has prompted studies of plausible associations of the virus with ReA. We present a case of ReA in a patient who survived COVID-19 and presented with joint affections. The patient, a 31-year-old man, presented with lower limb joints pain. SARS-CoV-2 was confirmed by PCR testing during COVID-19-associated pneumonia. Following a thorough examination and exclusion of all ReA-associated infections, a diagnosis of ReA after COVID-19 was confirmed. In addition, this article encompasses a study of similar clinical cases of ReA following COVID-19 reported worldwide.
摘要:
反应性关节炎(ReA)是通常由关节外细菌感染引发的临床病症,并且通常与HLA-B27的存在相关。虽然ReA传统上与胃肠道和泌尿生殖系统感染有关,其发病机制涉及导致关节病变的免疫和炎症反应。由SARS-CoV-2引起的COVID-19的出现促使人们研究该病毒与ReA的可能关联。我们介绍了一名存活于COVID-19并伴有关节病变的患者的ReA病例。病人,一个31岁的男人,表现为下肢关节疼痛。SARS-CoV-2在COVID-19相关肺炎期间通过PCR检测得到证实。在彻底检查和排除所有ReA相关感染后,确诊为COVID-19后的ReA。此外,本文涵盖了一项全球报道的COVID-19后ReA的类似临床病例的研究。
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