PDF(Pubmed)
Abstract：
Cancer-induced bone pain (CIBP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. CIBP constitutes a specific pain state with distinct characteristics; however, it shares similarities with inflammatory and neuropathic pain. At present, although various therapies have been developed for this condition, complete relief from CIBP in patients with cancer is yet to be achieved. Hence, it is urgent to study the mechanism underlying CIBP to develop efficient analgesic drugs. Herein, we focused on the peripheral mechanism associated with the initiation of CIBP, which involves tissue injury in the bone and changes in the tumor microenvironment (TME) and dorsal root ganglion. The nerve-cancer and cancer-immunocyte cross-talk in the TME creates circumstances that promote tumor growth and metastasis, ultimately leading to CIBP. The peripheral mechanism of CIBP and current treatments as well as potential therapeutic targets are discussed in this review.
摘要：
癌症诱导的骨痛（CIBP）是由原发性骨肿瘤或骨转移引起的一种持续或突破性疼痛。CIBP构成了具有独特特征的特定疼痛状态；然而，它与炎症和神经性疼痛有相似之处。目前,尽管已经针对这种情况开发了各种疗法，癌症患者的血压完全缓解仍有待实现。因此，迫切需要研究CIBP的作用机制，以开发有效的镇痛药物。在这里，我们专注于与CIBP启动相关的外周机制，其中涉及骨骼中的组织损伤以及肿瘤微环境（TME）和背根神经节的变化。TME中的神经癌症和癌症免疫细胞串扰创造了促进肿瘤生长和转移的环境，最终领导ToCIBP。本文综述了CIBP的外周机制和目前的治疗方法以及潜在的治疗靶点。
