关键词: Bioinsecticides Oral bioavailability Pests Snake venom Spider venom

Mesh : Animals Venoms Drosophila melanogaster Spider Venoms / toxicity Insecta Insecticides / toxicity Larva

来  源:   DOI:10.1016/j.toxicon.2023.107308

Abstract:
Animal venoms are a promising source of potential bioinsecticides. To find hits with pronounced oral insect toxicity, we screened 82 venoms using Achroia grisella (Lepidoptera) and Tenebrio molitor (Coleoptera) larvae, and adult Drosophila melanogaster (Diptera). We also injected the most potent venoms in adult D. melanogaster to compare their efficiency in different routes of administration. 18 venoms from spiders and snakes show high oral toxicity and can be further exploited to isolate new insecticides.
摘要:
动物毒液是潜在生物杀虫剂的有希望的来源。为了找到具有明显口腔昆虫毒性的命中物,我们用黄曲霉和黄粉虫幼虫筛选了82个毒液,和成年果蝇。我们还在成年D.melanogaster中注射了最有效的毒液,以比较它们在不同给药途径中的效率。我们发现了至少18种具有高口服毒性的毒液,可以进一步利用这些毒液来分离新的杀虫剂。
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