Abstract：
BACKGROUND: Current osteoporosis pharmacological treatment has undesirable side effects. There is increasing focus on naturally derived food substances that contain phytonutrients with antioxidant effects in promoting health and regulating immune response.
OBJECTIVE: This review aims to systematically evaluate the effectiveness of anthocyanin-rich foods on bone remodeling biomarkers in middle-aged and older adults (≥40 y old) at risk of osteoporosis.
METHODS: Randomized controlled trials were searched on 8 bibliographic databases of PubMed, Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Food Science and Technology Abstracts, Cochrane Library, and ProQuest.
METHODS: Thirteen studies were included in the meta-analysis. Receptor activator of nuclear factor kappa-B ligand (RANKL) is exhibited from osteoblastic cells that gathered osteoclasts to bone sites for bone resorption, accelerating bone loss. Anthocyanin-rich food consumption showed statistically nonsignificant effects, with no substantial heterogeneity on bone remodeling biomarkers. However, there was a significant increase in lumbar spine L1-L4 bone mineral density. Mild-to-small effects were seen to largely favor the consumption of anthocyanin-rich foods. Berries (d = -0.44) have a larger effect size of RANKL than plums (d = 0.18), with statistically significant subgroup differences. Random-effects meta-regression found body mass index, total attrition rate, total energy, and dietary carbohydrate and fat intake were significant covariates for the effect size of RANKL. All outcomes had low certainty of evidence.
CONCLUSIONS: Anthocyanin-rich foods may improve bone health in middle-aged and older adults at risk of osteoporosis. This review contributes to the growing interest in nutrient-rich foods as a low-cost and modifiable alternative to promote human health and reduce disease burden. Future high-quality studies with larger sample sizes and longer treatment durations are required to fully understand the effect of anthocyanin-rich foods on bone health.
BACKGROUND: PROSPERO registration no. CRD42022367136.
OBJECTIVE: This review aims to systematically evaluate the effectiveness of anthocyanin-rich foods on bone remodeling biomarkers in middle-aged and older adults (≥40 y old) at risk of osteoporosis.
METHODS: Randomized controlled trials were searched on 8 bibliographic databases of PubMed, Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Food Science and Technology Abstracts, Cochrane Library, and ProQuest.
METHODS: Thirteen studies were included in the meta-analysis. Receptor activator of nuclear factor kappa-B ligand (RANKL) is exhibited from osteoblastic cells that gathered osteoclasts to bone sites for bone resorption, accelerating bone loss. Anthocyanin-rich food consumption showed statistically nonsignificant effects, with no substantial heterogeneity on bone remodeling biomarkers. However, there was a significant increase in lumbar spine L1-L4 bone mineral density. Mild-to-small effects were seen to largely favor the consumption of anthocyanin-rich foods. Berries (d = -0.44) have a larger effect size of RANKL than plums (d = 0.18), with statistically significant subgroup differences. Random-effects meta-regression found body mass index, total attrition rate, total energy, and dietary carbohydrate and fat intake were significant covariates for the effect size of RANKL. All outcomes had low certainty of evidence.
CONCLUSIONS: Anthocyanin-rich foods may improve bone health in middle-aged and older adults at risk of osteoporosis. This review contributes to the growing interest in nutrient-rich foods as a low-cost and modifiable alternative to promote human health and reduce disease burden. Future high-quality studies with larger sample sizes and longer treatment durations are required to fully understand the effect of anthocyanin-rich foods on bone health.
BACKGROUND: PROSPERO registration no. CRD42022367136.
摘要：
背景：目前的骨质疏松症药物治疗具有不良副作用。人们越来越关注含有植物营养素的天然食物物质，这些物质具有促进健康和调节免疫反应的抗氧化作用。
目的：本综述旨在系统评估富含花青素的食物对有骨质疏松风险的中老年人（≥40岁）骨重塑生物标志物的有效性。
方法：在PubMed的8个书目数据库中搜索随机对照试验，Embase,Scopus,WebofScience,护理和相关健康文献累积指数(CINAHL)，食品科学与技术文摘,科克伦图书馆,和ProQuest。
方法：13项研究纳入荟萃分析。核因子κB配体（RANKL）的受体激活剂从成骨细胞中表现出来，这些成骨细胞聚集了破骨细胞，以骨吸收，加速骨质流失.富含花青素的食物消费显示出统计学上不显著的影响，骨重建生物标志物没有实质性异质性。然而,腰椎L1-L4骨密度显著增加.观察到轻度到轻度的影响在很大程度上有利于食用富含花青素的食物。浆果（d=-0.44）比李子（d=0.18）具有更大的RANKL效应大小，亚组差异具有统计学意义。随机效应元回归发现体重指数，总流失率，总能量,膳食碳水化合物和脂肪摄入量是RANKL效应大小的显著协变量。所有结果的证据确定性都很低。
结论：富含花青素的食物可以改善有骨质疏松风险的中老年人的骨骼健康。这篇综述有助于人们对营养丰富的食物越来越感兴趣，将其作为促进人类健康和减少疾病负担的低成本和可修改的替代品。未来需要具有更大样本量和更长治疗持续时间的高质量研究，以充分了解富含花青素的食物对骨骼健康的影响。
背景：PROSPERO注册号。CRD42022367136。
目的：本综述旨在系统评估富含花青素的食物对有骨质疏松风险的中老年人（≥40岁）骨重塑生物标志物的有效性。
方法：在PubMed的8个书目数据库中搜索随机对照试验，Embase,Scopus,WebofScience,护理和相关健康文献累积指数(CINAHL)，食品科学与技术文摘,科克伦图书馆,和ProQuest。
方法：13项研究纳入荟萃分析。核因子κB配体（RANKL）的受体激活剂从成骨细胞中表现出来，这些成骨细胞聚集了破骨细胞，以骨吸收，加速骨质流失.富含花青素的食物消费显示出统计学上不显著的影响，骨重建生物标志物没有实质性异质性。然而,腰椎L1-L4骨密度显著增加.观察到轻度到轻度的影响在很大程度上有利于食用富含花青素的食物。浆果（d=-0.44）比李子（d=0.18）具有更大的RANKL效应大小，亚组差异具有统计学意义。随机效应元回归发现体重指数，总流失率，总能量,膳食碳水化合物和脂肪摄入量是RANKL效应大小的显著协变量。所有结果的证据确定性都很低。
结论：富含花青素的食物可以改善有骨质疏松风险的中老年人的骨骼健康。这篇综述有助于人们对营养丰富的食物越来越感兴趣，将其作为促进人类健康和减少疾病负担的低成本和可修改的替代品。未来需要具有更大样本量和更长治疗持续时间的高质量研究，以充分了解富含花青素的食物对骨骼健康的影响。
背景：PROSPERO注册号。CRD42022367136。
