PDF(Pubmed)
Abstract：
BACKGROUND: Glioblastoma usually recurs locally and extracranial metastases are rare. Most patients with extracranial metastases experience recurrence of the primary intracranial tumor. Lymph node metastases are often detected based on lymphadenopathy or symptoms caused by other metastatic sites.
METHODS: Herein, we report a case of glioblastoma with lymph node metastasis in which the patient was asymptomatic but exhibited gradually increasing C-reactive protein levels prior to becoming febrile 9 months after the initial C-reactive protein increase. Diagnosis of lymph node metastasis that was delayed because the patient had a fever of unknown origin, no signs of infection, and the primary intracranial tumor did not recur. Chest computed tomography indicated supraclavicular, mediastinal, and hilar lymphadenopathy, and biopsy identified lymph node metastasis of glioblastoma. This is the fifth reported case of lymph node metastasis without intracranial recurrence.
CONCLUSIONS: C-reactive protein levels may be a diagnostic marker for lymph node metastasis in patients with glioblastoma. Further evaluation is needed to elucidate the role of CRP in glioblastoma with lymph node metastasis.
METHODS: Herein, we report a case of glioblastoma with lymph node metastasis in which the patient was asymptomatic but exhibited gradually increasing C-reactive protein levels prior to becoming febrile 9 months after the initial C-reactive protein increase. Diagnosis of lymph node metastasis that was delayed because the patient had a fever of unknown origin, no signs of infection, and the primary intracranial tumor did not recur. Chest computed tomography indicated supraclavicular, mediastinal, and hilar lymphadenopathy, and biopsy identified lymph node metastasis of glioblastoma. This is the fifth reported case of lymph node metastasis without intracranial recurrence.
CONCLUSIONS: C-reactive protein levels may be a diagnostic marker for lymph node metastasis in patients with glioblastoma. Further evaluation is needed to elucidate the role of CRP in glioblastoma with lymph node metastasis.
摘要：
背景：胶质母细胞瘤通常局部复发，颅外转移很少见。大多数颅外转移患者的原发性颅内肿瘤复发。淋巴结转移通常基于淋巴结病或由其他转移部位引起的症状来检测。
方法：这里，我们报道了一例伴有淋巴结转移的胶质母细胞瘤,患者无症状,但在最初的C反应蛋白升高后9个月出现发热前C反应蛋白水平逐渐升高.淋巴结转移的诊断延迟，因为病人有不明原因的发热，没有感染的迹象,原发性颅内肿瘤没有复发。胸部CT显示锁骨上，纵隔,肺门淋巴结肿大,活检发现胶质母细胞瘤淋巴结转移。这是第五例报道的无颅内复发的淋巴结转移病例。
结论：C反应蛋白水平可能是胶质母细胞瘤患者淋巴结转移的诊断指标。需要进一步评估以阐明CRP在伴有淋巴结转移的胶质母细胞瘤中的作用。
方法：这里，我们报道了一例伴有淋巴结转移的胶质母细胞瘤,患者无症状,但在最初的C反应蛋白升高后9个月出现发热前C反应蛋白水平逐渐升高.淋巴结转移的诊断延迟，因为病人有不明原因的发热，没有感染的迹象,原发性颅内肿瘤没有复发。胸部CT显示锁骨上，纵隔,肺门淋巴结肿大,活检发现胶质母细胞瘤淋巴结转移。这是第五例报道的无颅内复发的淋巴结转移病例。
结论：C反应蛋白水平可能是胶质母细胞瘤患者淋巴结转移的诊断指标。需要进一步评估以阐明CRP在伴有淋巴结转移的胶质母细胞瘤中的作用。
