Abstract:
Acute inflammation resolution acts as a vital process for active host response, tissue support, and homeostasis maintenance, during which resolvin D (RvD) and E (RvE) as mediators derived from omega-3 polyunsaturated fatty acids display specific and stereoselective anti-inflammations like restricting neutrophil infiltration and pro-resolving activities. On the other side of the coin, potent macrophage-mediated apoptotic cell clearance, namely efferocytosis, is essential for successful inflammation resolution. Further studies mentioned a linkage between efferocytosis and resolvins. For instance, resolvin D1 (RvD1), which is endogenously formed from docosahexaenoic acid within the inflammation resolution, thereby provoking efferocytosis. There is still limited information regarding the mechanism of action of RvD1-related efferocytosis enhancement at the molecular level. The current review article was conducted to explore recent data on how the efferocytosis process and resolvins relate to each other during the inflammation resolution in illness and health. Understanding different aspects of this connection sheds light on new curative approaches for medical conditions caused by defective efferocytosis and disrupted inflammation resolution.
摘要:
急性炎症消退是宿主主动反应的重要过程,组织支持,和稳态维持,在此过程中,作为源自omega-3多不饱和脂肪酸的介体的消退素D(RvD)和E(RvE)显示出特异性和立体选择性的抗炎作用,例如限制中性粒细胞浸润和促消退活性。在硬币的另一面,有效的巨噬细胞介导的凋亡细胞清除,即红细胞增多症,对于成功解决炎症至关重要。进一步的研究提到了红细胞增生和消退素之间的联系。例如,resolvinD1(RvD1),它是由二十二碳六烯酸在炎症消退中内源性形成的,从而引起红细胞增多。在分子水平上,关于RvD1相关的有效细胞增多作用机制的信息仍然有限。进行当前的评论文章是为了探索有关在疾病和健康中炎症消退期间有效细胞增多过程和消退素如何相互关联的最新数据。了解这种联系的不同方面,可以为由有缺陷的红细胞增多和炎症消退中断引起的医疗状况提供新的治疗方法。