PDF(Pubmed)
Abstract：
Acute pancreatitis is a frequent cause of hospitalization, with the most common triggers being alcohol consumption and gallstones. Although the incidence of drug-induced pancreatitis remains low, it is steadily increasing due to the advent of newly discovered broad-spectrum antibiotics targeting multi-drug resistant organisms. Tigecycline, a broad-spectrum intravenous antibiotic derived from the tetracycline class, was approved by the FDA in 2005 for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired pneumonia. It has activity against vancomycin-resistant Enterococcus, Methicillin-resistant Staphylococcus aureus, multi-drug-resistant Acinetobacter baumannii, multi-drug-resistant Stenotrophomonas maltophilia, and Extended Spectrum Beta-lactamase (ESBL) producing Enterobacter species. However, it was later discovered that tigecycline can cause acute pancreatitis. We present a case of a 27-year-old female patient who was admitted to the emergency department with abdominal pain and was subsequently diagnosed with tigecycline-induced pancreatitis based on the clinical resolution after withdrawal of the drug.
摘要：
急性胰腺炎是住院的常见原因，最常见的诱因是饮酒和胆结石。尽管药物性胰腺炎的发病率仍然很低，由于新发现的针对多药耐药生物的广谱抗生素的出现，它正在稳步增加。替加环素,一种来自四环素类的广谱静脉内抗生素，2005年被FDA批准用于治疗复杂的皮肤和皮肤结构感染，复杂的腹腔感染，和社区获得性肺炎。它具有抗万古霉素抗性肠球菌的活性，耐甲氧西林金黄色葡萄球菌,多重耐药鲍曼不动杆菌,多重耐药嗜麦芽窄食单胞菌,和产超广谱β-内酰胺酶(ESBL)的肠杆菌种类。然而,后来发现替加环素可引起急性胰腺炎。我们介绍了一例27岁的女性患者，该患者因腹痛入院急诊科，随后根据停药后的临床疗效被诊断为替加环素诱发的胰腺炎。
