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Abstract：
The effects of oral health on mortality have been reported; however, the association between mortality and Oral Health-Related Quality of Life (OHQOL) is unknown. We investigated the effect of OHQOL on total mortality in a cohort consisting of dentists.
In this cohort study, we analyzed data from the Longitudinal Evaluation of Multi-phasic, Odonatological and Nutritional Associations in Dentists study. We conducted a baseline survey of general and oral health factors. We called for 31,178 participants and collected responses from 10,256 participants. We followed up with 10,114 participants (mean age ± standard deviation, 52.4 ± 12.1 years; females, 8.9%) for 7.7 years, until March 2014, to determine the average total mortality. OHQOL was assessed using the General Oral Health Assessment Index (GOHAI). The total score was divided into quartiles (Q1 ≤ 51.6, Q2 = 51.7-56.7, Q3 = 56.8-59.9, and Q4 = 60.0), with higher GOHAI scores indicating better OHQOL (score range, 12-60). The association between OHQOL and total mortality was analyzed using the Cox proportional hazards model.
We documented 460 deaths. Males with low GOHAI scores possessed a remarkably high risk of total mortality. The multivariate adjusted-hazard ratios (aHRs), were 1.93 (95% confidence interval [CI], 1.07 - 3.48) for Q1, 1.69 (95% CI, 0.90 - 3.17) for Q2, and 0.65 (95% CI, 0.29 - 1.46) for Q3, relative to Q4 (trend p = 0.001). The aHRs in the multivariate model with all background variables were 1.69 (95% CI, 1.15-2.46) for Q1, 1.53 (95% CI, 1.04-2.27) for Q2, and 1.09 (95% CI, 0.71-1.70) for Q3, relative to Q4 (trend p = 0.001). In females, there was no significant association between the quartiles, in both the multivariate-adjusted model (trend p = 0.52) and multivariate-adjusted model with all background variables (trend p = 0.79).
A lower OHQOL indicated an increased risk of total mortality in dentists. OHQOL may be used as an indicator for selecting treatment plans and personalized care interventions, thus contributing to increased healthy life expectancy.
Aichi Cancer Center, Nagoya University Graduate School of Medicine, and Hiroshima University (Approval numbers: 33, 632-3, 8-21, and E2019-1603).
In this cohort study, we analyzed data from the Longitudinal Evaluation of Multi-phasic, Odonatological and Nutritional Associations in Dentists study. We conducted a baseline survey of general and oral health factors. We called for 31,178 participants and collected responses from 10,256 participants. We followed up with 10,114 participants (mean age ± standard deviation, 52.4 ± 12.1 years; females, 8.9%) for 7.7 years, until March 2014, to determine the average total mortality. OHQOL was assessed using the General Oral Health Assessment Index (GOHAI). The total score was divided into quartiles (Q1 ≤ 51.6, Q2 = 51.7-56.7, Q3 = 56.8-59.9, and Q4 = 60.0), with higher GOHAI scores indicating better OHQOL (score range, 12-60). The association between OHQOL and total mortality was analyzed using the Cox proportional hazards model.
We documented 460 deaths. Males with low GOHAI scores possessed a remarkably high risk of total mortality. The multivariate adjusted-hazard ratios (aHRs), were 1.93 (95% confidence interval [CI], 1.07 - 3.48) for Q1, 1.69 (95% CI, 0.90 - 3.17) for Q2, and 0.65 (95% CI, 0.29 - 1.46) for Q3, relative to Q4 (trend p = 0.001). The aHRs in the multivariate model with all background variables were 1.69 (95% CI, 1.15-2.46) for Q1, 1.53 (95% CI, 1.04-2.27) for Q2, and 1.09 (95% CI, 0.71-1.70) for Q3, relative to Q4 (trend p = 0.001). In females, there was no significant association between the quartiles, in both the multivariate-adjusted model (trend p = 0.52) and multivariate-adjusted model with all background variables (trend p = 0.79).
A lower OHQOL indicated an increased risk of total mortality in dentists. OHQOL may be used as an indicator for selecting treatment plans and personalized care interventions, thus contributing to increased healthy life expectancy.
Aichi Cancer Center, Nagoya University Graduate School of Medicine, and Hiroshima University (Approval numbers: 33, 632-3, 8-21, and E2019-1603).
摘要：
背景：口腔健康对死亡率的影响已有报道；然而，死亡率与口腔健康相关生活质量(OHQOL)之间的关联尚不清楚.我们调查了由牙医组成的队列中OHQOL对总死亡率的影响。
方法：在这项队列研究中，我们分析了多相纵向评估的数据，牙本质学和营养协会在牙医研究。我们对一般和口腔健康因素进行了基线调查。我们招募了31,178名参与者，并收集了10,256名参与者的回复。我们随访了10,114名参与者(平均年龄±标准差，52.4±12.1岁；女性，8.9%）为7.7年，直到2014年3月，以确定平均总死亡率。使用一般口腔健康评估指数（GOHAI）评估OHQOL。总分分为四分位数(Q1≤51.6,Q2=51.7-56.7,Q3=56.8-59.9,Q4=60.0),GOHAI分数越高，表明OHQOL(分数范围，12-60).使用Cox比例风险模型分析OHQOL与总死亡率之间的关联。
结果：我们记录了460例死亡。GOHAI得分较低的男性总死亡率的风险非常高。多元调整风险比(aHRs)，为1.93(95%置信区间[CI]，相对于第四季度，第一季度为1.07-3.48），第二季度为1.69（95%CI，0.90-3.17），第三季度为0.65（95%CI，0.29-1.46）（趋势p=0.001）。在具有所有背景变量的多变量模型中，相对于Q4，Q1为1.69（95％CI，1.15-2.46），Q2为1.53（95％CI，1.04-2.27），Q3为1.09（95％CI，0.71-1.70）（趋势p=0.001）。在女性中，四分位数之间没有明显的关联，在多变量调整模型（趋势p=0.52）和具有所有背景变量的多变量调整模型（趋势p=0.79）中。
结论：较低的OHQOL表明牙医总死亡率的风险增加。OHQOL可以用作选择治疗计划和个性化护理干预的指标。从而有助于增加健康的预期寿命。
背景：爱知癌症中心，名古屋大学医学研究生院，广岛大学（批准号：33、632-3、8-21和E2019-1603）。
方法：在这项队列研究中，我们分析了多相纵向评估的数据，牙本质学和营养协会在牙医研究。我们对一般和口腔健康因素进行了基线调查。我们招募了31,178名参与者，并收集了10,256名参与者的回复。我们随访了10,114名参与者(平均年龄±标准差，52.4±12.1岁；女性，8.9%）为7.7年，直到2014年3月，以确定平均总死亡率。使用一般口腔健康评估指数（GOHAI）评估OHQOL。总分分为四分位数(Q1≤51.6,Q2=51.7-56.7,Q3=56.8-59.9,Q4=60.0),GOHAI分数越高，表明OHQOL(分数范围，12-60).使用Cox比例风险模型分析OHQOL与总死亡率之间的关联。
结果：我们记录了460例死亡。GOHAI得分较低的男性总死亡率的风险非常高。多元调整风险比(aHRs)，为1.93(95%置信区间[CI]，相对于第四季度，第一季度为1.07-3.48），第二季度为1.69（95%CI，0.90-3.17），第三季度为0.65（95%CI，0.29-1.46）（趋势p=0.001）。在具有所有背景变量的多变量模型中，相对于Q4，Q1为1.69（95％CI，1.15-2.46），Q2为1.53（95％CI，1.04-2.27），Q3为1.09（95％CI，0.71-1.70）（趋势p=0.001）。在女性中，四分位数之间没有明显的关联，在多变量调整模型（趋势p=0.52）和具有所有背景变量的多变量调整模型（趋势p=0.79）中。
结论：较低的OHQOL表明牙医总死亡率的风险增加。OHQOL可以用作选择治疗计划和个性化护理干预的指标。从而有助于增加健康的预期寿命。
背景：爱知癌症中心，名古屋大学医学研究生院，广岛大学（批准号：33、632-3、8-21和E2019-1603）。
