Abstract：
Coronaviruses (CoVs) are a significant group of pathogens that pose a serious threat to both human and animal health, with some being zoonotic and displaying frequent cross-species transmission. Human CoV-OC43 (HCoV-OC43) is one of the four common human CoVs that can cause seasonal mild to moderate respiratory diseases in humans. In this study, we identified HCoV-OC43 for the first time in two asymptomatic pet hamsters, which share a high similarity with the human-derived HCoV-OC43 strain, suggesting potential cross-species transmission of HCoV-OC43 to pet hamsters. The finding emphasizes the need to strengthen pathogen monitoring of livestock and pets in close contact with humans to provide early warning of public safety.
摘要：
冠状病毒（CoV）是一类重要的病原体，对人类和动物健康构成严重威胁，其中一些是人畜共患的，并显示出频繁的跨物种传播。人类CoV-OC43（HCoV-OC43）是四种常见的人类CoV之一，可引起人类季节性轻度至中度呼吸道疾病。在这项研究中,我们首次在两只无症状的宠物仓鼠中鉴定出HCoV-OC43，与人类来源的HCoV-OC43菌株有很高的相似性，提示HCoV-OC43潜在的跨物种传播给宠物仓鼠。该发现强调需要加强对与人类密切接触的牲畜和宠物的病原体监测，以提供公共安全的预警。
