PDF(Pubmed)
Abstract：
Approximately half of adolescents encounter a mismatch between their sleep patterns on school days and free days, also referred to as \"social jetlag.\" This condition has been linked to various adverse outcomes, such as poor sleep, cognitive deficits, and mental disorders. However, prior research was unsuccessful in accounting for other variables that are correlated with social jetlag, including sleep duration and quality. To address this limitation, we applied a propensity score matching method on a sample of 6335 11-12-year-olds from the 2-year follow-up (FL2) data of the Adolescent Brain Cognitive Development study. We identified 2424 pairs of participants with high sleep-corrected social jetlag (SJLsc, over 1 hour) and low SJLsc (<= 1 hour) at FL2 (1728 pairs have neuroimaging data), as well as 1626 pairs at 3-year follow-up (FL3), after matching based on 11 covariates including socioeconomic status, demographics, and sleep duration and quality. Our results showed that high SJLsc, as measured by the Munich Chronotype Questionnaire, was linked to reduced crystallized intelligence (CI), lower school performance-grades, and decreased functional connectivity between cortical networks and subcortical regions, specifically between cingulo-opercular network and right hippocampus. Further mediation and longitudinal mediation analyses revealed that this connection mediated the associations between SJLsc and CI at FL2, and between SJLsc and grades at both FL2 and FL3. We validated these findings by replicating these results using objective SJLsc measurements obtained via Fitbit watches. Overall, our study highlights the negative association between social jetlag and CI during early adolescence.
摘要：
大约一半的青少年在上学日和空闲日的睡眠模式不匹配，也称为“社会时差”。这种情况与各种不良后果有关，比如睡眠不好，认知缺陷,和精神障碍。然而,先前的研究在考虑与社会时差相关的其他变量方面没有成功，包括睡眠时间和质量。为了解决这个限制，我们对青少年脑认知发育(ABCD)研究的2年随访(FL2)数据中的6335名11~12岁人群样本应用了倾向评分匹配方法.我们确定了2424对具有高睡眠校正社会时差的参与者(SJLsc，超过1小时）和低SJLsc（<=1小时）在FL2（1728对有神经影像学数据），以及1626对三年随访(FL3)，在基于包括社会经济地位在内的11个协变量进行匹配后，人口统计，睡眠时间和质量。我们的结果表明，高SJLsc，根据慕尼黑时间型问卷的测量，与结晶智力下降有关，较低的学校表现-成绩，皮质网络和皮质下区域之间的功能连通性下降，特别是在扣带手术网络和右侧海马之间。进一步的调解和纵向调解分析表明，这种联系介导了SJLsc与FL2结晶智力之间的关联，以及SJLsc与FL2和FL3等级之间的关联。我们通过使用Fitbit手表获得的客观SJLsc测量结果来复制这些结果，从而验证了这些发现。总的来说,我们的研究强调了青春期早期社会时差与智力结晶之间的负相关.
