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Abstract：
Placental growth factor (PlGF), an important polypeptide hormone, plays an important regulatory role in various physiological processes. Observational studies have shown that PlGF is associated with the risk of coronary heart disease (CHD). However, the causal association between PlGF and CHD is unclear at present. This study aimed to investigate the causal association between genetically predicted PlGF levels and CHD.
Single nucleotide polymorphisms (SNPs) associated with PlGF were selected as instrumental variables (IVs) to evaluate the causal association between genetically predicted circulating PlGF levels and CHD risk by two-sample Mendelian randomization (MR).
Inverse variance weighted (IVW) analysis showed that there was a suggestive causal association between genetically predicted PlGF level and the risk of CHD (OR = 0.79, 95% CI: 0.66-0.95, P = 0.011) overall. In addition, PlGF levels had a significant negative causal association with the risk of myocardial infarction (OR = 0.83, 95% CI: 0.72-0.95, P = 0.007). A negative correlation trend was found between PlGF level and the risk of angina pectoris (OR = 0.89, 95% CI: 0.79-1.01, P = 0.067). In addition, PlGF levels had a significant negative association with the risk of unstable angina pectoris (OR = 0.78, 95% CI: 0.64-0.94, P = 0.008). PlGF levels were negatively correlated with CHD events with suggestive significance (OR = 0.89, 95% CI: 0.80-0.99, P = 0.046).
Genetically predicted circulating PlGF levels are causally associated with the risk of CHD, especially acute coronary syndrome, and PlGF is a potential therapeutic target for CHD.
Single nucleotide polymorphisms (SNPs) associated with PlGF were selected as instrumental variables (IVs) to evaluate the causal association between genetically predicted circulating PlGF levels and CHD risk by two-sample Mendelian randomization (MR).
Inverse variance weighted (IVW) analysis showed that there was a suggestive causal association between genetically predicted PlGF level and the risk of CHD (OR = 0.79, 95% CI: 0.66-0.95, P = 0.011) overall. In addition, PlGF levels had a significant negative causal association with the risk of myocardial infarction (OR = 0.83, 95% CI: 0.72-0.95, P = 0.007). A negative correlation trend was found between PlGF level and the risk of angina pectoris (OR = 0.89, 95% CI: 0.79-1.01, P = 0.067). In addition, PlGF levels had a significant negative association with the risk of unstable angina pectoris (OR = 0.78, 95% CI: 0.64-0.94, P = 0.008). PlGF levels were negatively correlated with CHD events with suggestive significance (OR = 0.89, 95% CI: 0.80-0.99, P = 0.046).
Genetically predicted circulating PlGF levels are causally associated with the risk of CHD, especially acute coronary syndrome, and PlGF is a potential therapeutic target for CHD.
摘要：
目标：胎盘生长因子（PlGF），一种重要的多肽激素，在各种生理过程中起着重要的调节作用。观察性研究表明，PlGF与冠心病（CHD）的风险有关。然而,PlGF与CHD之间的因果关系目前尚不清楚.本研究旨在探讨基因预测的PlGF水平与CHD之间的因果关系。
方法：选择与PlGF相关的单核苷酸多态性(SNPs)作为工具变量(IVs)，通过双样本孟德尔随机化(MR)评估遗传预测的循环PlGF水平与CHD风险之间的因果关系。
结果：逆方差加权（IVW）分析显示，基因预测的PlGF水平与冠心病风险之间存在总体因果关系（OR=0.79，95％CI：0.66-0.95，P=0.011）。此外,PlGF水平与心肌梗死风险呈显著负因果关系(OR=0.83,95%CI:0.72-0.95,P=0.007)。PlGF水平与心绞痛发病风险呈负相关(OR=0.89,95%CI:0.79~1.01,P=0.067)。此外,PlGF水平与不稳定型心绞痛发病风险呈显著负相关(OR=0.78,95%CI:0.64~0.94,P=0.008)。PlGF水平与冠心病事件呈负相关(OR=0.89,95%CI:0.80～0.99,P=0.046)。
结论：遗传预测的循环PlGF水平与冠心病的风险有因果关系，尤其是急性冠脉综合征,PlGF是CHD的潜在治疗靶点。
方法：选择与PlGF相关的单核苷酸多态性(SNPs)作为工具变量(IVs)，通过双样本孟德尔随机化(MR)评估遗传预测的循环PlGF水平与CHD风险之间的因果关系。
结果：逆方差加权（IVW）分析显示，基因预测的PlGF水平与冠心病风险之间存在总体因果关系（OR=0.79，95％CI：0.66-0.95，P=0.011）。此外,PlGF水平与心肌梗死风险呈显著负因果关系(OR=0.83,95%CI:0.72-0.95,P=0.007)。PlGF水平与心绞痛发病风险呈负相关(OR=0.89,95%CI:0.79~1.01,P=0.067)。此外,PlGF水平与不稳定型心绞痛发病风险呈显著负相关(OR=0.78,95%CI:0.64~0.94,P=0.008)。PlGF水平与冠心病事件呈负相关(OR=0.89,95%CI:0.80～0.99,P=0.046)。
结论：遗传预测的循环PlGF水平与冠心病的风险有因果关系，尤其是急性冠脉综合征,PlGF是CHD的潜在治疗靶点。
