Abstract：
OBJECTIVE: The role of alcohol in young-onset breast cancer (YOBC) is unclear. We examined associations between lifetime alcohol consumption and YOBC in the Young Women\'s Health History Study, a population-based case-control study of breast cancer among Non-Hispanic Black and White women < 50 years of age.
METHODS: Breast cancer cases (n = 1,812) were diagnosed in the Metropolitan Detroit and Los Angeles County SEER registry areas, 2010-2015. Controls (n = 1,381) were identified through area-based sampling and were frequency-matched to cases by age, site, and race. Alcohol consumption and covariates were collected from in-person interviews. Weighted multivariable logistic regression was conducted to calculate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for associations between alcohol consumption and YOBC overall and by subtype (Luminal A, Luminal B, HER2, or triple negative).
RESULTS: Lifetime alcohol consumption was not associated with YOBC overall or with subtypes (all ptrend ≥ 0.13). Similarly, alcohol consumption in adolescence, young and middle adulthood was not associated with YOBC (all ptrend ≥ 0.09). An inverse association with triple-negative YOBC, however, was observed for younger age at alcohol use initiation (< 18 years vs. no consumption), aOR (95% CI) = 0.62 (0.42, 0.93). No evidence of statistical interaction by race or household poverty was observed.
CONCLUSIONS: Our findings suggest alcohol consumption has a different association with YOBC than postmenopausal breast cancer-lifetime consumption was not linked to increased risk and younger age at alcohol use initiation was associated with a decreased risk of triple-negative YOBC. Future studies on alcohol consumption in YOBC subtypes are warranted.
METHODS: Breast cancer cases (n = 1,812) were diagnosed in the Metropolitan Detroit and Los Angeles County SEER registry areas, 2010-2015. Controls (n = 1,381) were identified through area-based sampling and were frequency-matched to cases by age, site, and race. Alcohol consumption and covariates were collected from in-person interviews. Weighted multivariable logistic regression was conducted to calculate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for associations between alcohol consumption and YOBC overall and by subtype (Luminal A, Luminal B, HER2, or triple negative).
RESULTS: Lifetime alcohol consumption was not associated with YOBC overall or with subtypes (all ptrend ≥ 0.13). Similarly, alcohol consumption in adolescence, young and middle adulthood was not associated with YOBC (all ptrend ≥ 0.09). An inverse association with triple-negative YOBC, however, was observed for younger age at alcohol use initiation (< 18 years vs. no consumption), aOR (95% CI) = 0.62 (0.42, 0.93). No evidence of statistical interaction by race or household poverty was observed.
CONCLUSIONS: Our findings suggest alcohol consumption has a different association with YOBC than postmenopausal breast cancer-lifetime consumption was not linked to increased risk and younger age at alcohol use initiation was associated with a decreased risk of triple-negative YOBC. Future studies on alcohol consumption in YOBC subtypes are warranted.
摘要：
目的：酒精在青年型乳腺癌（YOBC）中的作用尚不清楚。我们在年轻女性的健康史研究中检查了终生饮酒与YOBC之间的关系，非西班牙裔黑人和白人女性<50岁的乳腺癌人群病例对照研究。
方法：在底特律大都会和洛杉矶县SEER注册区诊断出乳腺癌病例（n=1,812）。2010-2015。对照（n=1,381）通过基于面积的采样进行识别，并按年龄与病例进行频率匹配，site,和种族。酒精消耗和协变量是从面对面访谈中收集的。进行加权多变量逻辑回归，以计算酒精消耗与整体和亚型之间的关联的调整比值比（aOR）和95％置信区间（CI）（LuminalA，管腔B,HER2或三阴性)。
结果：终身饮酒与整体或亚型（所有ptrend≥0.13）无相关性。同样，青春期饮酒,青年和中年与YOBC无关（所有ptrend≥0.09）。与三负YOBC成反比，然而,在开始饮酒时观察到年龄较小(<18岁vs.无消费)，OR(95%CI)=0.62(0.42,0.93)。没有观察到种族或家庭贫困之间的统计相互作用的证据。
结论：我们的研究结果表明，与绝经后乳腺癌相比，饮酒与YOBC的相关性不同，终生饮酒与风险增加无关，开始饮酒时年龄较小与三阴性YOBC的风险降低有关。有必要对YOBC亚型的饮酒进行未来研究。
方法：在底特律大都会和洛杉矶县SEER注册区诊断出乳腺癌病例（n=1,812）。2010-2015。对照（n=1,381）通过基于面积的采样进行识别，并按年龄与病例进行频率匹配，site,和种族。酒精消耗和协变量是从面对面访谈中收集的。进行加权多变量逻辑回归，以计算酒精消耗与整体和亚型之间的关联的调整比值比（aOR）和95％置信区间（CI）（LuminalA，管腔B,HER2或三阴性)。
结果：终身饮酒与整体或亚型（所有ptrend≥0.13）无相关性。同样，青春期饮酒,青年和中年与YOBC无关（所有ptrend≥0.09）。与三负YOBC成反比，然而,在开始饮酒时观察到年龄较小(<18岁vs.无消费)，OR(95%CI)=0.62(0.42,0.93)。没有观察到种族或家庭贫困之间的统计相互作用的证据。
结论：我们的研究结果表明，与绝经后乳腺癌相比，饮酒与YOBC的相关性不同，终生饮酒与风险增加无关，开始饮酒时年龄较小与三阴性YOBC的风险降低有关。有必要对YOBC亚型的饮酒进行未来研究。
