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Abstract：
To explore the interaction of instrumental activities of daily living (IADLs) and dual sensory function on cognition in the elderly. A cross-sectional survey was conducted in six general hospitals in China, from October 2022 to December 2022. Data collection included general information, IADLs scale, self-reported sensory function questionnaire, and mini-mental state examination (MMSE). Binary logistic regression was used to examine the association between factors and cognition. The interactive effect was evaluated by synergy index (S), relative excess risk due to interaction (RERI), and attributable proportion due to interaction (AP). The odds ratio (OR) of IADLs decline in cognition is 4.412 (95% confidence interval [CI]: 3.633-5.358, p < 0.001); the OR of dual sensory difficulty on cognition is 2.502 (95% CI: 1.272-4.921, p = 0.008). The OR of interaction between IADLs decline and dual sensory difficulty on cognition is 13.737 (95% CI: 9.726-19.400, p < 0.001). RERI (95% CI) = 7.823 (3.230-12.417), AP (95% CI) = 0.570 (0.392-0.747), S (95% CI) = 2.593 (1.616-4.160). IADLs decline and dual sensory difficulty are associated with cognitive decline. IADLs decline and dual sensory difficulty have interaction with cognitive decline; the interaction is greater than the sum effect of those two on cognitive decline independently. Sensory and IADLs assessment can be used as early screening items for cognition among the elderly. In addition, protecting sensory function and maintaining IADLs in the elderly can help protect their cognition.
摘要：
探讨日常生活工具性活动(IADLs)与双重感觉功能对老年人认知功能的影响。在中国六家综合医院进行了横断面调查，从2022年10月到2022年12月。数据收集包括一般信息，IADLs量表,自我报告的感觉功能问卷，和小型精神状态检查（MMSE）。二元logistic回归用于检查因素与认知之间的关联。通过协同指数(S)评价交互效应，相互作用导致的相对超额风险(RERI)，和归因于互动的比例(AP)。IADLs认知功能下降的比值比（OR）为4.412（95％置信区间[CI]：3.633-5.358，p<0.001）；双重感觉困难对认知功能的OR为2.502（95％CI：1.272-4.921，p=0.008）。IADL下降和双重感觉困难对认知的交互作用的OR为13.737（95％CI：9.726-19.400，p<0.001）。RERI（95%CI）=7.823（3.230-12.417），AP（95%CI）=0.570（0.392-0.747），S（95%CI）=2.593（1.616-4.160）。IADLs下降和双重感觉困难与认知能力下降有关。IADL下降和双重感觉困难与认知能力下降有交互作用；交互作用大于这两者对认知能力下降的总和。感觉和IADLs评估可作为老年人认知的早期筛查项目。此外,保护老年人的感觉功能和维持IADLs有助于保护老年人的认知功能。
