Abstract：
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, autoimmune disease that mostly affects the synovial joints. It has been hypothesized that dietary and other environmental and lifestyle factors contribute to the development of RA and its severity.
OBJECTIVE: The present study aims to measure the effect of the Mediterranean diet (MedDiet) on the disease activity scores (DAS28) among patients with RA.
METHODS: Adult patients who satisfied the American College of Rheumatology (ACR) classification criteria for RA from major hospitals in Kuwait were evaluated. A cross-sectional study conducted on 754 RA patients visits aged (21-79) years. Patients were evaluated using the DAS28. Patients\' levels of adherence to the MedDiet are assessed using a validated 14-item Questionnaire (paper or web-based). The data was analyzed using both multivariate and univariate statistics. Multivariate logistic regression was used to analyze the statistical relationship between MedDiet and RA disease activity.
RESULTS: The finding suggests that a MedDiet can have a positive impact on DAS28 among patients with RA. In the DAS28 cohort (DAS28 < 3.2, DAS28 ≥ 3.2), several Mediterranean survey components showed statistically significant differences. Patients with a Mediterranean score ≤ 5 was more likely to have hazard effects for DAS28 than those with a Mediterranean score of ≥10 (HR = 0.17, CI [0.08-0.37], p < .001). The finding shows that, Mediterranean levels ≤5, on biologics treatment, CRP, and patient global assessment were significantly associated with overall survival. Additionally, the MedDiet was found to be a significant predictor of DAS28 in the random forest decision tree plot, along with tender, RF, and creatinine. MedDiet patients had a lower DAS28 score than others.
CONCLUSIONS: The findings suggest that optimal drug treatment and a restrictive diet can help to improve DAS28 score for patients with RA. More patients in the cohort DAS28 <3.2 used olive oil, servings of vegetables, fruits, and legumes. In contrast, more patients in the cohort DAS28 ≥ 3.2 consumed red meat, butter, sweetened or soft drinks, cakes, cookies, or biscuits, and tomato sauce.
OBJECTIVE: The present study aims to measure the effect of the Mediterranean diet (MedDiet) on the disease activity scores (DAS28) among patients with RA.
METHODS: Adult patients who satisfied the American College of Rheumatology (ACR) classification criteria for RA from major hospitals in Kuwait were evaluated. A cross-sectional study conducted on 754 RA patients visits aged (21-79) years. Patients were evaluated using the DAS28. Patients\' levels of adherence to the MedDiet are assessed using a validated 14-item Questionnaire (paper or web-based). The data was analyzed using both multivariate and univariate statistics. Multivariate logistic regression was used to analyze the statistical relationship between MedDiet and RA disease activity.
RESULTS: The finding suggests that a MedDiet can have a positive impact on DAS28 among patients with RA. In the DAS28 cohort (DAS28 < 3.2, DAS28 ≥ 3.2), several Mediterranean survey components showed statistically significant differences. Patients with a Mediterranean score ≤ 5 was more likely to have hazard effects for DAS28 than those with a Mediterranean score of ≥10 (HR = 0.17, CI [0.08-0.37], p < .001). The finding shows that, Mediterranean levels ≤5, on biologics treatment, CRP, and patient global assessment were significantly associated with overall survival. Additionally, the MedDiet was found to be a significant predictor of DAS28 in the random forest decision tree plot, along with tender, RF, and creatinine. MedDiet patients had a lower DAS28 score than others.
CONCLUSIONS: The findings suggest that optimal drug treatment and a restrictive diet can help to improve DAS28 score for patients with RA. More patients in the cohort DAS28 <3.2 used olive oil, servings of vegetables, fruits, and legumes. In contrast, more patients in the cohort DAS28 ≥ 3.2 consumed red meat, butter, sweetened or soft drinks, cakes, cookies, or biscuits, and tomato sauce.
摘要：
背景：类风湿性关节炎（RA）是一种慢性，主要影响滑膜关节的自身免疫性疾病。据推测，饮食和其他环境和生活方式因素有助于RA的发展及其严重程度。
目的：本研究旨在测量地中海饮食（MedDiet）对RA患者疾病活动评分（DAS28）的影响。
方法：对科威特主要医院符合美国风湿病学会（ACR）RA分类标准的成年患者进行评估。对754名年龄（21-79岁）的RA患者进行的横断面研究。使用DAS28对患者进行评估。使用经过验证的14项问卷（纸质或基于网络的）评估患者对MedDiet的依从性水平。使用多变量和单变量统计学分析数据。采用多因素logistic回归分析MedDiet与RA疾病活动度的统计学关系。
结果：该发现表明，在RA患者中，MedDiet可以对DAS28产生积极影响。在DAS28队列中（DAS28<3.2，DAS28≥3.2），地中海调查的几个组成部分显示出统计学上的显着差异。地中海评分≤5的患者比地中海评分≥10的患者更有可能对DAS28产生危险影响(HR=0.17,CI[0.08-0.37],p<.001)。这一发现表明,地中海水平≤5，生物制品治疗，CRP,患者总体评估与总生存率显著相关.此外,在随机森林决策树图中，MedDiet被发现是DAS28的重要预测因子，随着招标，射频,和肌酐。MedDiet患者的DAS28评分低于其他患者。
结论：研究结果表明，最佳药物治疗和限制性饮食有助于改善RA患者的DAS28评分。DAS28<3.2队列中更多的患者使用橄榄油，一份蔬菜，水果,和豆类。相比之下,队列中DAS28≥3.2的患者食用红肉，黄油,甜味或软饮料，蛋糕,饼干,或者饼干,还有番茄酱.
目的：本研究旨在测量地中海饮食（MedDiet）对RA患者疾病活动评分（DAS28）的影响。
方法：对科威特主要医院符合美国风湿病学会（ACR）RA分类标准的成年患者进行评估。对754名年龄（21-79岁）的RA患者进行的横断面研究。使用DAS28对患者进行评估。使用经过验证的14项问卷（纸质或基于网络的）评估患者对MedDiet的依从性水平。使用多变量和单变量统计学分析数据。采用多因素logistic回归分析MedDiet与RA疾病活动度的统计学关系。
结果：该发现表明，在RA患者中，MedDiet可以对DAS28产生积极影响。在DAS28队列中（DAS28<3.2，DAS28≥3.2），地中海调查的几个组成部分显示出统计学上的显着差异。地中海评分≤5的患者比地中海评分≥10的患者更有可能对DAS28产生危险影响(HR=0.17,CI[0.08-0.37],p<.001)。这一发现表明,地中海水平≤5，生物制品治疗，CRP,患者总体评估与总生存率显著相关.此外,在随机森林决策树图中，MedDiet被发现是DAS28的重要预测因子，随着招标，射频,和肌酐。MedDiet患者的DAS28评分低于其他患者。
结论：研究结果表明，最佳药物治疗和限制性饮食有助于改善RA患者的DAS28评分。DAS28<3.2队列中更多的患者使用橄榄油，一份蔬菜，水果,和豆类。相比之下,队列中DAS28≥3.2的患者食用红肉，黄油,甜味或软饮料，蛋糕,饼干,或者饼干,还有番茄酱.
