Abstract：
The microbiota-gut-brain axis denotes a two-way system of interactions between the gut and the brain, comprising three key components: (1) gut microbiota, (2) intermediates and (3) mental ailments. These constituents communicate with one another to induce changes in the host\'s mood, cognition and demeanor. Knowledge concerning the regulation of the host central nervous system by gut microbiota is fragmented and mostly confined to disorganized or semi-structured unrestricted texts. Such a format hinders the exploration and comprehension of unknown territories or the further advancement of artificial intelligence systems. Hence, we collated crucial information by scrutinizing an extensive body of literature, amalgamated the extant knowledge of the microbiota-gut-brain axis and depicted it in the form of a knowledge graph named MMiKG, which can be visualized on the GraphXR platform and the Neo4j database, correspondingly. By merging various associated resources and deducing prospective connections between gut microbiota and the central nervous system through MMiKG, users can acquire a more comprehensive perception of the pathogenesis of mental disorders and generate novel insights for advancing therapeutic measures. As a free and open-source platform, MMiKG can be accessed at http://yangbiolab.cn:8501/ with no login requirement.
摘要：
微生物群-肠道-大脑轴表示肠道和大脑之间的双向相互作用系统，包括三个关键组成部分：(1)肠道微生物群，（2）中间体和（3）精神疾病。这些成分相互交流，以引起宿主情绪的变化，认知和举止。有关肠道微生物群调节宿主中枢神经系统的知识是零散的，并且大多局限于无序或半结构化的非限制性文本。这种格式阻碍了对未知领域的探索和理解或人工智能系统的进一步发展。因此，我们通过仔细检查大量文献来整理关键信息，合并了现有的关于微生物群-肠-脑轴的知识，并以名为MMiKG的知识图的形式对其进行了描述，可以在GraphXR平台和Neo4j数据库上可视化，相应地。通过合并各种相关资源，并通过MMiKG推断肠道微生物群与中枢神经系统之间的前瞻性联系，使用者可以更全面地了解精神障碍的发病机制，并为推进治疗措施提供新的见解。作为一个免费的开源平台，可以在http://yangbiolab访问MMiKG。cn:8501/没有登录要求。
