PDF(Pubmed)
Abstract：
Peptidyl arginine deiminase 6 (PADI6) is a maternal factor that is vital for early embryonic development. Deletion and mutations of its encoding gene in female mice or women lead to early embryonic developmental arrest, female infertility, maternal imprinting defects and hyperproliferation of the trophoblast. PADI6 is the fifth and least well-characterized member of the peptidyl arginine deiminases (PADIs), which catalyse the post-translational conversion of arginine to citrulline. It is less conserved than the other PADIs, and currently has no reported catalytic activity. While there are many suggested functions of PADI6 in the early mouse embryo, including in embryonic genome activation, cytoplasmic lattice formation, maternal mRNA and ribosome regulation, and organelle distribution, the molecular mechanisms of its function remain unknown. In this review, we discuss what is known about the function of PADI6 and highlight key outstanding questions that must be answered if we are to understand the crucial role it plays in early embryo development and female fertility. This article is part of the Theo Murphy meeting issue \'The virtues and vices of protein citrullination\'.
摘要：
肽基精氨酸脱亚胺酶6（PADI6）是对早期胚胎发育至关重要的母体因子。其编码基因在雌性小鼠或雌性小鼠中的缺失和突变导致早期胚胎发育停滞，女性不孕症,母体印迹缺陷和滋养细胞过度增殖。PADI6是肽基精氨酸脱亚胺酶（PADIs）的第五个也是特征最少的成员，催化精氨酸翻译后转化为瓜氨酸。它比其他PADI保守得少，目前尚无催化活性报道。虽然PADI6在小鼠早期胚胎中有许多建议的功能，包括胚胎基因组激活，细胞质晶格形成，母体mRNA和核糖体调节，和细胞器分布，其功能的分子机制仍然未知。在这次审查中,我们讨论了关于PADI6功能的已知情况，并强调了关键的悬而未决的问题，如果我们要了解PADI6在早期胚胎发育和女性生育中的关键作用，这些问题必须回答。本文是TheoMurphy会议议题“蛋白质瓜氨酸化的优点和缺点”的一部分。
