PDF(Pubmed)
Abstract：
UNASSIGNED: Alzheimer\'s disease (AD) is more prevalent in women than in men; however, there is a discrepancy in research on sex differences in AD. The human brain is a large-scale network with hub regions forming a central core, the rich-club, which is vital to cognitive functions. However, it is unknown whether alterations in the rich-clubs in AD differ between men and women. We aimed to investigate sex differences in the rich-club organization in the brains of patients with AD.
UNASSIGNED: In total, 260 cognitively unimpaired individuals with negative amyloid positron emission tomography (PET) scans, 281 with prodromal AD (mild cognitive impairment due to AD) and 285 with AD dementia who confirmed with positive amyloid PET scans participated in the study. We obtained high-resolution T1-weighted and diffusion tensor images and performed network analysis.
UNASSIGNED: We observed sex differences in the rich-club and feeder connections in patients with AD, suggesting lower structural connectivity strength in women than in men. We observed a significant group-by-sex interaction in the feeder connections, particularly in the thalamus. In addition, the connectivity strength of the thalamus in the feeder connections was significantly correlated with general cognitive function in only men with prodromal AD and women with AD dementia.
UNASSIGNED: Our findings provide important evidence for sex-specific alterations in the structural brain network related to AD.
UNASSIGNED: In total, 260 cognitively unimpaired individuals with negative amyloid positron emission tomography (PET) scans, 281 with prodromal AD (mild cognitive impairment due to AD) and 285 with AD dementia who confirmed with positive amyloid PET scans participated in the study. We obtained high-resolution T1-weighted and diffusion tensor images and performed network analysis.
UNASSIGNED: We observed sex differences in the rich-club and feeder connections in patients with AD, suggesting lower structural connectivity strength in women than in men. We observed a significant group-by-sex interaction in the feeder connections, particularly in the thalamus. In addition, the connectivity strength of the thalamus in the feeder connections was significantly correlated with general cognitive function in only men with prodromal AD and women with AD dementia.
UNASSIGNED: Our findings provide important evidence for sex-specific alterations in the structural brain network related to AD.
摘要：
■阿尔茨海默病（AD）在女性中比在男性中更普遍；然而，关于AD性别差异的研究存在差异。人脑是一个大规模的网络，枢纽区域形成一个中心核心，富人俱乐部,这对认知功能至关重要。然而,尚不清楚AD中富人俱乐部的改变是否在男性和女性之间有所不同。我们旨在调查AD患者大脑中富裕俱乐部组织的性别差异。
■总共，260名认知未受损的个体，淀粉样蛋白正电子发射断层扫描（PET）扫描为阴性，281名患有前驱AD（由于AD引起的轻度认知障碍）和285名患有AD痴呆的淀粉样蛋白PET扫描阳性的患者参加了该研究。我们获得了高分辨率的T1加权和扩散张量图像，并进行了网络分析。
■我们观察到AD患者的富俱乐部和饲养者连接的性别差异，表明女性的结构连接强度低于男性。我们观察到在饲养连接中存在明显的按性别分组的相互作用，特别是在丘脑。此外,仅在患有前驱AD的男性和患有AD痴呆的女性中，饲养连接中丘脑的连接强度与一般认知功能显着相关。
■我们的发现为与AD相关的结构性脑网络中的性别特异性改变提供了重要证据。
■总共，260名认知未受损的个体，淀粉样蛋白正电子发射断层扫描（PET）扫描为阴性，281名患有前驱AD（由于AD引起的轻度认知障碍）和285名患有AD痴呆的淀粉样蛋白PET扫描阳性的患者参加了该研究。我们获得了高分辨率的T1加权和扩散张量图像，并进行了网络分析。
■我们观察到AD患者的富俱乐部和饲养者连接的性别差异，表明女性的结构连接强度低于男性。我们观察到在饲养连接中存在明显的按性别分组的相互作用，特别是在丘脑。此外,仅在患有前驱AD的男性和患有AD痴呆的女性中，饲养连接中丘脑的连接强度与一般认知功能显着相关。
■我们的发现为与AD相关的结构性脑网络中的性别特异性改变提供了重要证据。
