Abstract：
Catalytic asymmetric methods for the synthesis of synthetically versatile P-stereogenic building blocks offer an efficient and practical approach for the diversity-oriented preparation of P-chiral phosphorus compounds. Herein, we report the first nickel-catalyzed synthesis of P-stereogenic secondary aminophosphine-boranes by the asymmetric addition of primary phosphines to azo compounds. We further demonstrate that the P-H and P-N bonds on these phosphanyl hydrazine building blocks can be reacted sequentially and stereospecifically to access various P-stereogenic compounds with structural diversity.
摘要：
合成通用P-立体异构结构单元的催化不对称方法为P-手性磷化合物的多样性取向制备提供了一种有效且实用的方法。在这里，我们报道了第一个镍催化的合成P-立体异构体仲氨基膦-硼烷通过伯膦不对称加成到偶氮化合物。我们进一步证明，这些磷酰肼结构单元上的P-H和P-N键可以顺序和立体特异性地反应，以获得具有结构多样性的各种P-立体异构化合物。
