PDF(Pubmed)
Abstract：
Inconsistent findings have been reported regarding the associations between hypertensive disorders in pregnancy (HDP) and infant neurodevelopment. Leveraging data from the Jiangsu Birth Cohort, in the present study, we re-visited such associations in one-year-old infants from 2576 singleton pregnancies and 261 twin pregnancies. We first assessed infant neurodevelopment by the Bayley Scales of Infant and Toddler Development Screening Test (the Third Edition), and then estimated its association with maternal HDP using general linear regression models and Poisson regression models. In singleton pregnancies, compared with mothers unexposed to HDP, infants born to mothers with chronic hypertension exhibited a lower score ( β, -0.67; 95% confidence interval [CI], -1.19--0.15) and a higher risk of \"non-optimal\" gross motor development (risk ratio [RR], 2.21; 95% CI, 1.02-4.79); in twin pregnancies, infants born to mothers with HDP exhibited lower scores in cognition ( β, -0.49; 95% CI, -0.96--0.01), receptive communication ( β, -0.55; 95% CI, -1.03--0.06), and gross motor ( β, -0.44; 95% CI, -0.86--0.03), and at a higher risk of \"non-optimal\" gross motor development (RR, 2.12; 95% CI, 1.16-3.88). These findings indicate that infants born to mothers with HDP may have inferior neurodevelopment outcomes at the age of one year.
摘要：
关于妊娠高血压疾病（HDP）与婴儿神经发育之间的关联，已经报道了不一致的发现。利用江苏出生队列的数据，在本研究中,我们与2576例单胎妊娠和261例双胎妊娠重新探讨了这种关联.我们首先在一岁时通过Bayley婴儿和幼儿发育筛查量表（第三版）进行了婴儿神经发育评估。然后，我们使用一般线性回归模型和泊松回归模型来估计母亲HDP与一岁婴儿神经发育之间的关联。在单胎怀孕中，与未接触HDP的母亲相比，患有慢性高血压的母亲所生的婴儿得分较低(β，-0.67；95%置信区间[CI]，-1.19--0.15)和更高的“非最佳”电机发展风险(风险比[RR]，2.21；95%CI，1.02-4.79)；在双胎妊娠中，患有HDP的母亲所生的婴儿在认知方面表现出较低的得分(β，-0.49；95%CI，-0.96--0.01），接受性沟通(β，-0.55；95%CI，-1.03--0.06），和粗大马达(β，-0.44；95%CI，-0.86--0.03），并且处于“非最佳”总运动发展的较高风险(RR，2.12；95%CI，1.16-3.88）。这些发现表明，患有HDP的母亲所生的婴儿在一岁时可能具有较差的神经发育结果。
