PDF(Pubmed)
Abstract：
Following vaccination with adenoviral vector-based ChAdOx1 nCoV-19, serious neurological adverse events have been reported. Here we report two cases who presented with quadriparesis following the adenoviral vector-based ChAdOx1 nCoV-19 vaccine. A 55-year-old male patient presented with quadriparesis after 8 days of the second dose of ChAdOx1 nCoV-19 vaccination. Imaging showed features of stroke with right basilar artery thrombosis; he was started on anticoagulation following which the patient\'s neurological status improved and he was discharged during the 7th week of hospital stay. A 19-year-old male patient presented with quadriparesis after 16 days of the first dose of ChAdOx1 nCoV-19 vaccination. Cerebral spinal fluid and nerve conduction study was suggestive of Guillain-Barre syndrome (GBS). Two doses of intravenous immunoglobulin were given, following which the patient\'s neurological status improved and he was discharged in the 11th week of his hospital stay. Awareness of neurological adverse effects and emphasis on the underlying mechanism of vaccine-induced thrombotic thrombocytopenia (VITT) and molecular mimicry in patients presenting with quadriparesis following ChAdOx1 nCoV-19 vaccination is important.
摘要：
在用基于腺病毒载体的ChAdOx1nCoV-19疫苗接种后,已经报道了严重的神经系统不良事件。在这里，我们报告了两例在基于腺病毒载体的ChAdOx1nCoV-19疫苗后出现四肢轻瘫的病例。一名55岁的男性患者在第二次接种ChAdOx1nCoV-19疫苗8天后出现四肢轻瘫。影像学表现为右基底动脉血栓形成的卒中特征；患者开始抗凝治疗，随后患者的神经状况得到改善，在住院第7周出院。一名19岁男性患者在首次接种ChAdOx1nCoV-19疫苗16天后出现四肢轻瘫。脑脊液和神经传导研究提示格林-巴利综合征（GBS）。给予两剂静脉注射免疫球蛋白，随后，患者的神经状况得到改善，他在住院的第11周出院。在ChAdOx1nCoV-19疫苗接种后出现四肢轻瘫的患者中，对神经系统不良反应的认识以及对疫苗诱导的血栓性血小板减少症（VITT）和分子模仿的潜在机制的重视很重要。
