PDF(Pubmed)
Abstract：
UNASSIGNED: The application of blood concentrates has gained popularity in dentistry in recent years. Platelet-rich fibrin (PRF) has been discussed frequently due to a high content of growth factors and the option of chair-side manufacturing in a simple centrifugation process. PRF is free from adjuvants and inexpensive to produce. The number of studies reporting beneficial effects of PRF in various clinical applications such as alveolar ridge preservation, sinus floor elevation, management and prevention of medical-related osteonecrosis of the jaw, third molar extractions, and guided bone regeneration in dentistry has increased recently. However, to date, neither clinical recommendations nor guidelines are available. The present narrative review aims to summarize the level of evidence on the clinical application of PRF within the field of oral surgery and implantology.
UNASSIGNED: A literature search in Pubmed and Medline has identified 34 articles as a basis for this narrative review. The effectiveness of the clinical application of PRF has been analyzed for five indications within dentistry: medical-related osteonecrosis of the jaw, wisdom tooth extraction, guided bone regeneration, sinus floor elevation, and alveolar ridge preservation. The amount of data for third molar extractions, socket preservation, and guided bone regeneration is extensive. Less data were available for the use of PRF in combination with sinus floor elevations. There is a lack of studies with scientific evidence on PRF and medical-related osteonecrosis of the jaw; however, studies positively impact patient-related outcome measures. Most studies report on beneficial effects when PRF is additionally applied in intrabony defects. There is no evidence of the positive effects of PRF combined with bone graft materials during sinus floor elevation. However, some benefits are reported with PRF as a sole filling material.
UNASSIGNED: Many recently published studies show the positive clinical impact of PRF. Yet, further research is needed to ensure the validity of the evidence.
UNASSIGNED: A literature search in Pubmed and Medline has identified 34 articles as a basis for this narrative review. The effectiveness of the clinical application of PRF has been analyzed for five indications within dentistry: medical-related osteonecrosis of the jaw, wisdom tooth extraction, guided bone regeneration, sinus floor elevation, and alveolar ridge preservation. The amount of data for third molar extractions, socket preservation, and guided bone regeneration is extensive. Less data were available for the use of PRF in combination with sinus floor elevations. There is a lack of studies with scientific evidence on PRF and medical-related osteonecrosis of the jaw; however, studies positively impact patient-related outcome measures. Most studies report on beneficial effects when PRF is additionally applied in intrabony defects. There is no evidence of the positive effects of PRF combined with bone graft materials during sinus floor elevation. However, some benefits are reported with PRF as a sole filling material.
UNASSIGNED: Many recently published studies show the positive clinical impact of PRF. Yet, further research is needed to ensure the validity of the evidence.
摘要：
■近年来，血液浓缩物的应用在牙科领域得到了普及。由于生长因子含量高，并且可以在简单的离心过程中选择椅子侧制造，因此经常讨论富血小板纤维蛋白（PRF）。PRF不含佐剂并且生产便宜。许多研究报告了PRF在各种临床应用中的有益作用，例如牙槽，窦底抬高,医学相关的颌骨坏死的管理和预防，第三摩尔萃取，和引导骨再生在牙科最近有所增加。然而,到目前为止,既没有临床建议,也没有指南.本综述旨在总结PRF在口腔外科和种植领域的临床应用证据水平。
■在Pubmed和Medline中进行的文献检索已经确定了34篇文章作为本叙事综述的基础。PRF的临床应用的有效性已经在牙科中的五个适应症进行了分析：医学相关的颌骨坏死，智齿拔除,引导骨再生，窦底抬高,和牙槽脊保存。第三磨牙提取的数据量，插座保存,引导骨再生是广泛的。PRF与窦底抬高结合使用的数据较少。缺乏关于PRF和医学相关的颌骨坏死的科学证据的研究；然而，研究对患者相关结局指标产生积极影响。大多数研究报告了当PRF额外应用于骨内缺损时的有益效果。在窦底抬高过程中，没有证据表明PRF与植骨材料结合具有积极作用。然而,据报道，PRF作为唯一的填充材料有一些好处。
■许多最近发表的研究表明PRF的积极临床影响。然而，需要进一步研究以确保证据的有效性。
■在Pubmed和Medline中进行的文献检索已经确定了34篇文章作为本叙事综述的基础。PRF的临床应用的有效性已经在牙科中的五个适应症进行了分析：医学相关的颌骨坏死，智齿拔除,引导骨再生，窦底抬高,和牙槽脊保存。第三磨牙提取的数据量，插座保存,引导骨再生是广泛的。PRF与窦底抬高结合使用的数据较少。缺乏关于PRF和医学相关的颌骨坏死的科学证据的研究；然而，研究对患者相关结局指标产生积极影响。大多数研究报告了当PRF额外应用于骨内缺损时的有益效果。在窦底抬高过程中，没有证据表明PRF与植骨材料结合具有积极作用。然而,据报道，PRF作为唯一的填充材料有一些好处。
■许多最近发表的研究表明PRF的积极临床影响。然而，需要进一步研究以确保证据的有效性。
