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Abstract：
UNASSIGNED: The aim of this study was to assess intraocular inflammation in patients with active and inactive Graves\' ophthalmopathy (GO) using an aqueous laser flash meter and to assess its relationship with thyroid hormones, antibodies, and clinical activity score (CAS).
UNASSIGNED: Forty patients (29 females and 11 males) were included in the study. The patients were divided into two groups according to CAS; patients with CAS <3 (inactive) were included in Group 1 and patients with CAS ≥3 (active) were included in Group 2. The laser flare meter was used to measure the flare of aqueous humor. Each patient\'s ocular findings, thyroid hormone, and antibody levels were also recorded.
UNASSIGNED: The mean age of patients was 46.88±11.79 years in Group 1 and 44.50±12.59 years in Group 2 (p=0.555). The mean CAS was 0.88±0.65 in Group 1 and 3.57±0.85 in Group 2 (p<0.001). The mean aqueous flare was 6.5±2.2 ph/ms in Group 1 and 7.0±6.4 ph/ms in Group 2 (p=0.73). Hertel exophthalmometry, intraocular pressure (IOP), antithyroglobulin antibody, and thyroid stimulating hormone receptor antibody (TRAb) levels were similar in both groups (each p>0.05). There was no correlation between aqueous flare value and CAS, Hertel exophthalmometry, IOP, thyroid hormone, and antibody levels (each p>0.05). There was a significant correlation between CAS and antibody levels (each p<0.05).
UNASSIGNED: Flare values that are not much above the normal range may be an indication that intraocular inflammation is not elevated in GO patients. This suggests that the damage to the blood-aqueous barrier in these patients is not severe enough to increase intraocular inflammation.
UNASSIGNED: Forty patients (29 females and 11 males) were included in the study. The patients were divided into two groups according to CAS; patients with CAS <3 (inactive) were included in Group 1 and patients with CAS ≥3 (active) were included in Group 2. The laser flare meter was used to measure the flare of aqueous humor. Each patient\'s ocular findings, thyroid hormone, and antibody levels were also recorded.
UNASSIGNED: The mean age of patients was 46.88±11.79 years in Group 1 and 44.50±12.59 years in Group 2 (p=0.555). The mean CAS was 0.88±0.65 in Group 1 and 3.57±0.85 in Group 2 (p<0.001). The mean aqueous flare was 6.5±2.2 ph/ms in Group 1 and 7.0±6.4 ph/ms in Group 2 (p=0.73). Hertel exophthalmometry, intraocular pressure (IOP), antithyroglobulin antibody, and thyroid stimulating hormone receptor antibody (TRAb) levels were similar in both groups (each p>0.05). There was no correlation between aqueous flare value and CAS, Hertel exophthalmometry, IOP, thyroid hormone, and antibody levels (each p>0.05). There was a significant correlation between CAS and antibody levels (each p<0.05).
UNASSIGNED: Flare values that are not much above the normal range may be an indication that intraocular inflammation is not elevated in GO patients. This suggests that the damage to the blood-aqueous barrier in these patients is not severe enough to increase intraocular inflammation.
摘要：
■本研究的目的是使用水性激光闪光计评估活动性和非活动性Graves眼病（GO）患者的眼内炎症，并评估其与甲状腺激素的关系，抗体，和临床活动评分（CAS）。
■40名患者（29名女性和11名男性）被纳入研究。根据CAS将患者分为两组；CAS<3（不活动）的患者纳入第1组，CAS≥3（活动）的患者纳入第2组。激光耀斑仪用于测量房水耀斑。每个病人的眼部检查结果,甲状腺激素,和抗体水平也被记录。
■第1组患者的平均年龄为46.88±11.79岁，第2组患者为44.50±12.59岁（p=0.555）。第1组平均CAS为0.88±0.65，第2组平均CAS为3.57±0.85（p<0.001）。第1组的平均房水发作为6.5±2.2ph/ms，第2组的平均房水发作为7.0±6.4ph/ms（p=0.73）。赫特尔眼球测量,眼内压（IOP），抗甲状腺球蛋白抗体，促甲状腺激素受体抗体(TRAb)水平在两组中相似(均p>0.05)。房水耀斑值与CAS无相关性,赫特尔眼球测量,IOP,甲状腺激素,和抗体水平（每个p>0.05）。CAS和抗体水平之间存在显著的相关性(每个P<0.05)。
■不超过正常范围的耀斑值可能是GO患者眼内炎症未升高的迹象。这表明对这些患者的血-水屏障的损伤并不严重到足以增加眼内炎症。
■40名患者（29名女性和11名男性）被纳入研究。根据CAS将患者分为两组；CAS<3（不活动）的患者纳入第1组，CAS≥3（活动）的患者纳入第2组。激光耀斑仪用于测量房水耀斑。每个病人的眼部检查结果,甲状腺激素,和抗体水平也被记录。
■第1组患者的平均年龄为46.88±11.79岁，第2组患者为44.50±12.59岁（p=0.555）。第1组平均CAS为0.88±0.65，第2组平均CAS为3.57±0.85（p<0.001）。第1组的平均房水发作为6.5±2.2ph/ms，第2组的平均房水发作为7.0±6.4ph/ms（p=0.73）。赫特尔眼球测量,眼内压（IOP），抗甲状腺球蛋白抗体，促甲状腺激素受体抗体(TRAb)水平在两组中相似(均p>0.05)。房水耀斑值与CAS无相关性,赫特尔眼球测量,IOP,甲状腺激素,和抗体水平（每个p>0.05）。CAS和抗体水平之间存在显著的相关性(每个P<0.05)。
■不超过正常范围的耀斑值可能是GO患者眼内炎症未升高的迹象。这表明对这些患者的血-水屏障的损伤并不严重到足以增加眼内炎症。
