PDF(Pubmed)
Abstract：
Given the emergence of the coronavirus disease 2019 (COVID-19), zoonoses have raised in the spotlight of the scientific community. Animals have a pivotal role not only for this infection, but also for many other recent emerging and re-emerging viral diseases, where they may represent both intermediate hosts and/or vectors for zoonoses diffusion. Today, roughly two-thirds of human infections are derived from animal origins; therefore, the search for new broad-spectrum antiviral molecules is mandatory to prevent, control and eradicate future epidemic outbreaks. Host defense peptides, derived from skin secretions of amphibians, appear as the right alternative to common antimicrobial drugs. They are cationic peptides with an amphipathic nature widely described as antibacterial agents, but less is reported about their antiviral potential. In the present study, we evaluated the activity of five amphibian peptides, namely RV-23, AR-23, Hylin-a1, Deserticolin-1 and Hylaseptin-P1, against a wide panel of enveloped animal viruses. A strong virucidal effect was observed for RV-23, AR-23 and Hylin-a1 against bovine and caprine herpesviruses, canine distemper virus, bovine viral diarrhea virus, and Schmallenberg virus. Our results identified these three peptides as potential antiviral-led candidates with a putative therapeutic effect against several animal viruses.
摘要：
鉴于2019年冠状病毒病（COVID-19）的出现，人畜共患病已成为科学界的焦点。动物不仅对这种感染有关键作用，而且对于许多其他最近出现和重新出现的病毒性疾病，其中它们可以代表中间宿主和/或动物共患病扩散的载体。今天,大约三分之二的人类感染源于动物；因此，寻找新的广谱抗病毒分子是强制性的，控制和根除未来的疫情。宿主防御肽,来自两栖动物的皮肤分泌物，似乎是普通抗菌药物的正确替代品。它们是具有两亲性性质的阳离子肽，被广泛描述为抗菌剂，但关于它们抗病毒潜力的报道较少。在本研究中,我们评估了五种两栖动物肽的活性，即RV-23，AR-23，Hylin-a1，Deserticolin-1和Hylaseptin-P1，针对一组广泛的包膜动物病毒。RV-23，AR-23和Hylin-a1对牛和山羊疱疹病毒具有很强的杀病毒作用，犬瘟热病毒,牛病毒性腹泻病毒,和Schmallenberg病毒.我们的结果将这三种肽鉴定为潜在的抗病毒药物，对几种动物病毒具有推定的治疗作用。
