PDF(Pubmed)
Abstract：
Biofilms are responsible for the most prevalent oral infections such as caries, periodontal disease, and pulp and periapical lesions, which affect the quality of life of people. Antibiotics have been widely used to treat these conditions as therapeutic and prophylactic compounds. However, due to the emergence of microbial resistance to antibiotics, there is an urgent need to develop and evaluate new antimicrobial agents. This scoping review offers an extensive and detailed synthesis of the potential role of selenium nanoparticles (SeNPs) in combating oral pathogens responsible for causing infectious diseases. A systematic search was conducted up until May 2022, encompassing the MEDLINE, Embase, Scopus, and Lilacs databases. We included studies focused on evaluating the antimicrobial efficacy of SeNPs on planktonic and biofilm forms and their side effects in in vitro studies. The selection process and data extraction were carried out by two researchers independently. A qualitative synthesis of the results was performed. A total of twenty-two articles were considered eligible for this scoping review. Most of the studies reported relevant antimicrobial efficacy against C. albicans, S. mutans, E. faecalis, and P. gingivalis, as well as effective antioxidant activity and limited toxicity. Further research is mandatory to critically assess the effectiveness of this alternative treatment in ex vivo and in vivo settings, with detailed information about SeNPs concentrations employed, their physicochemical properties, and the experimental conditions to provide enough evidence to address the construction and development of well-designed and safe protocols.
摘要：
生物膜是最常见的口腔感染，如龋齿，牙周病,以及牙髓和根尖周病变，影响人们的生活质量。抗生素已作为治疗和预防化合物广泛用于治疗这些病症。然而,由于微生物对抗生素的耐药性的出现，迫切需要开发和评估新的抗微生物剂。此范围审查提供了硒纳米颗粒（SeNPs）在对抗导致传染病的口腔病原体中的潜在作用的广泛而详细的合成。直到2022年5月进行了系统的搜索，包括MEDLINE，Embase,Scopus,和紫丁香数据库。我们纳入了专注于评估SeNPs对浮游和生物膜形式的抗微生物功效及其在体外研究中的副作用的研究。选择过程和数据提取由两名研究人员独立进行。对结果进行定性合成。共有22篇文章被认为符合本次范围审查的条件。大多数研究报告了对白色念珠菌的相关抗菌功效，S.mutans，E.粪便，和牙龈卟啉单胞菌，以及有效的抗氧化活性和有限的毒性。进一步的研究是强制性的，以严格评估这种替代治疗在离体和体内设置的有效性，有关于使用的SeNPs浓度的详细信息，它们的物理化学性质，和实验条件，以提供足够的证据来解决精心设计和安全协议的建设和发展。
