PDF(Pubmed)
Abstract：
Human acellular amniotic membrane (HAAM) has emerged as a promising tool in the field of regenerative medicine, particularly for wound healing and tissue regeneration. HAAM provides a natural biological scaffold with low immunogenicity and good anti-infective and anti-scarring results. Despite its potential, the clinic application of HAAM faces challenges, particularly with respect to the preparation methods and its low mechanical strength. This review provides a comprehensive overview of HAAM, covering its preparation, sterilization, preclinical research, and clinical applications. This review also discusses promising decellularization and sterilization methods, such as Supercritical Carbon Dioxide (SC-CO2), and the need for further research into the regenerative mechanisms of HAAM. In addition, we discuss the potential of HAAM as a skin dressing and cell delivery system in preclinical research and clinical applications. Both the safety and effectiveness of HAAM have been validated by extensive research, which provides a robust foundation for its clinical application.
摘要：
人脱细胞羊膜（HAAM）已成为再生医学领域的一个有前途的工具，特别是伤口愈合和组织再生。HAAM提供了具有低免疫原性和良好抗感染和抗瘢痕形成结果的天然生物支架。尽管有潜力,HAAM的临床应用面临挑战，特别是关于制备方法及其低机械强度。这篇综述提供了对HAAM的全面概述，涵盖其准备工作，灭菌,临床前研究,和临床应用。这篇综述还讨论了有希望的脱细胞和灭菌方法，如超临界二氧化碳(SC-CO2)以及需要进一步研究HAAM的再生机制。此外,我们讨论了HAAM在临床前研究和临床应用中作为皮肤敷料和细胞递送系统的潜力。HAAM的安全性和有效性都得到了广泛研究的验证，为其临床应用提供了坚实的基础。
