PDF(Pubmed)
Abstract：
Osteoporosis is a serious implication of Turner syndrome (TS). Common methods for the treatment of TS are growth hormone (GHT) and estrogen replacement therapy (ERT). We examined the relationship between the treatment of TS and bone mineral density (BMD) of the lumbar spine. The purpose of our study was to show the currency of BMD states among patients with TS for treatment with GHT and ERT. We searched databases for studies published from inception to April 2023. The articles were related to TS, osteoporosis, ERT, GHT, BMD and treatment patients with TS. We applied the selection criteria: lumbar spine values at L1-L4; dual-energy X-ray absorptiometry (DXA); treatment which was applied: one group of articles: ERT and two group of articles: GHT; results performed as means ± SD. In total, 79 articles were analyzed, of which 20 studies were included and 5 were considered for meta-analysis. The total number of women in the articles selected was 71. Based on the results of the meta-analysis, the effect of ERT on BMD demonstrated a significant increase in BMD (the standardized mean difference in the random model was 0.593 g/cm2, 95% CI: 0.0705 to 1.116; p = 0.026), which showed that treatment with estrogen particularly increases bone mass during treatment, which contributes to reducing the risk of fractures. The effect of GHT on BMD demonstrated a non-significant decrease in BMD in patients with TS. The results for growth hormone show that this therapy does not improve bone density. However, our review emphasizes the beneficial effect of supplementing growth hormone (GH) on the clinical presentation of TS.
摘要：
骨质疏松症是特纳综合征（TS）的严重暗示。治疗TS的常用方法是生长激素(GHT)和雌激素替代疗法(ERT)。我们检查了TS的治疗与腰椎骨密度（BMD）之间的关系。我们研究的目的是显示使用GHT和ERT治疗的TS患者的BMD状态。我们在数据库中搜索了从开始到2023年4月发表的研究。这些文章与TS有关，骨质疏松,ERT,GHT,BMD和TS患者的治疗。我们应用了选择标准：L1-L4的腰椎值；双能X射线骨密度仪（DXA）；应用的治疗方法：一组文章：ERT和两组文章：GHT；结果以平均值±SD进行。总的来说,对79篇文章进行了分析，其中20项研究纳入,5项考虑进行荟萃分析.所选文章中的妇女总数为71名。根据荟萃分析的结果，ERT对BMD的影响表明BMD显着增加（随机模型中的标准化平均差为0.593g/cm2，95％CI：0.0705至1.116；p=0.026），这表明雌激素治疗在治疗期间特别增加骨量，这有助于降低骨折的风险。GHT对BMD的影响表明，TS患者的BMD没有显着降低。生长激素的结果表明，这种疗法不能改善骨密度。然而,我们的综述强调了补充生长激素(GH)对TS临床表现的有益作用.
