PDF(Pubmed)
Abstract：
Cancer is a worldwide health problem with high mortality in children and adults, making searching for novel bioactive compounds with potential use in cancer treatment essential. Piplartine, also known as piperlongumine, is an alkamide isolated from Piper longum Linn, with relevant therapeutic potential. Therefore, this review covered research on the antitumor activity of piplartine, and the studies reported herein confirm the antitumor properties of piplartine and highlight its possible application as an anticancer agent against various types of tumors. The evidence found serves as a reference for advancing mechanistic research on this metabolite and preparing synthetic derivatives or analogs with better antitumor activity in order to develop new drug candidates.
摘要：
癌症是一个世界性的健康问题，在儿童和成人中死亡率很高，寻找在癌症治疗中具有潜在用途的新型生物活性化合物至关重要。Piplartine,也被称为胡椒龙胺，是从PiperLongumLinn中分离出的烷酰胺，具有相关的治疗潜力。因此,本文综述了吡洛汀抗肿瘤活性的研究,本文报道的研究证实了吡普拉汀的抗肿瘤特性，并强调了其作为抗各种类型肿瘤的抗癌剂的可能应用。所发现的证据可为推进对该代谢物的机理研究以及制备具有更好抗肿瘤活性的合成衍生物或类似物以开发新的候选药物提供参考。
