PDF(Pubmed)
Abstract：
Antimicrobial resistance (AMR) presents a growing threat to global healthcare. This descriptive epidemiological study investigates the prevalence and characteristics of Enterobacterales with AMR factors in a tertiary teaching hospital in Italy over the course of the year 2021. In 2021, the prevalence of colonisation by Enterobacterales with AMR factors in patients was 1.08%. During the observation period, a total of 8834 rectal swabs were performed, with 1453 testing positive. A total of 5639 rectal swabs were performed according to a hospital procedure for the active screening of MDRO colonisation at the time of admission. Of these, 679 were positive for microorganisms under surveillance, and 74 patients were colonised with Enterobacterales, predominantly Klebsiella pneumoniae and Escherichia coli. Antibiotic resistance factors were observed in 61 of these 74 patients (82.43%) of these patients, with NDM and KPC being the most frequent resistance factors. A statistically significant trend in positive swabs was observed across different ward categories (surgery, ICUs, and medical wards). Regarding specific trends, the rate of positive admission screening in medical and surgical wards was higher than in ICU wards. The results highlight the ease with which Enterobacterales develops resistance across different ward categories. The findings underscore the need for adjusted screening protocols and tailored infection prevention strategies in various care settings.
摘要：
抗菌素耐药性(AMR)对全球医疗保健构成了日益严重的威胁。这项描述性流行病学研究调查了2021年意大利三级教学医院中具有AMR因子的肠杆菌的患病率和特征。2021年，具有AMR因子的肠杆菌在患者中定植的患病率为1.08%。在观察期间,共进行了8834次直肠拭子，1453检测呈阳性.根据医院程序，共进行了5639次直肠拭子，以在入院时积极筛查MDRO定植。其中,679个微生物在监测中呈阳性，74例患者被肠杆菌定植，主要是肺炎克雷伯菌和大肠杆菌。在这74例患者中有61例（82.43%）观察到抗生素耐药因素，NDM和KPC是最常见的耐药因素。在不同的病房类别(手术，ICUs,和医疗病房)。关于具体趋势，内科和外科病房的入院筛查阳性率高于ICU病房。结果突出了肠杆菌在不同病房类别中产生耐药性的容易程度。研究结果强调了在各种护理环境中需要调整的筛查方案和量身定制的感染预防策略。
