PDF(Pubmed)
Abstract：
Human respiratory syncytial virus (hRSV) is a significant cause of respiratory tract infections, particularly in young children and older adults. In this review, we aimed to comprehensively summarize what is known about the immune response to hRSV infection. We described the innate and adaptive immune components involved, including the recognition of RSV, the inflammatory response, the role of natural killer (NK) cells, antigen presentation, T cell response, and antibody production. Understanding the complex immune response to hRSV infection is crucial for developing effective interventions against this significant respiratory pathogen. Further investigations into the immune memory generated by hRSV infection and the development of strategies to enhance immune responses may hold promise for the prevention and management of hRSV-associated diseases.
摘要：
人呼吸道合胞病毒（hRSV）是呼吸道感染的重要原因，尤其是幼儿和老年人。在这次审查中,我们旨在全面总结对hRSV感染的免疫应答的已知情况。我们描述了所涉及的先天和适应性免疫成分，包括对RSV的认可,炎症反应，自然杀伤（NK）细胞的作用，抗原呈递,T细胞反应，和抗体生产。了解对hRSV感染的复杂免疫反应对于开发针对这种重要的呼吸道病原体的有效干预措施至关重要。对hRSV感染产生的免疫记忆的进一步研究以及增强免疫反应的策略的开发可能为预防和管理hRSV相关疾病带来希望。
