PDF(Pubmed)
Abstract：
Sepsis (and septic shock) is on of the most common causes of death worldwide. Bacteremia often, but not necessarily, occurs in septic patients, but the impact of true bacteremia on a patient\'s clinical characteristics and outcome remains unclear. The main aim of this study was to compare the characteristics and outcome of a well-defined cohort of 258 septic patients with and without bacteremia treated in the intensive care unit (ICU) of a tertiary center hospital in Prague, Czech Republic. As expected, more frequently, bacteremia was present in patients without previous antibiotic treatment. A higher proportion of bacteremia was observed in patients with infective endocarditis as well as catheter-related and soft tissue infections in contrast to respiratory sepsis. Multivariant analysis showed increased severity of clinical status and higher Charlson comorbidity index (CCI) as variables with significant influence on mortality. Bacteremia appears to be associated with higher mortality rates and length of ICU stay in comparison with nonbacteremic counterparts, but this difference did not reach statistical significance. The presence of bacteremia, apart from previous antibiotic treatment, may be related to the site of infection.
摘要：
脓毒症（和脓毒性休克）是全世界最常见的死亡原因。经常菌血症，但不一定,发生在败血症患者中，但真正的菌血症对患者临床特征和结局的影响尚不清楚。这项研究的主要目的是比较在布拉格三级中心医院的重症监护病房（ICU）中治疗的258例有和没有菌血症的败血症患者的特征和结果。捷克共和国。不出所料,更频繁地,未接受过抗生素治疗的患者存在菌血症.与呼吸道败血症相比，感染性心内膜炎以及导管相关和软组织感染患者的菌血症比例更高。多变量分析显示，临床状态的严重程度增加和Charlson合并症指数（CCI）升高是对死亡率有重大影响的变量。与非菌血症者相比，菌血症似乎与更高的死亡率和ICU住院时间有关。但这种差异没有达到统计学意义。菌血症的存在,除了以前的抗生素治疗，可能与感染部位有关。
