PDF(Pubmed)
Abstract：
The rising prevalence of tick-borne infections (TBIs) necessitates further attention. This study retrospectively investigated the types of TBIs, symptoms, and if combination antibiotics were helpful within a patient cohort at an infectious disease clinic in Ireland. In this chart audit of 301 individuals (184 female, 117 male) tested for TBIs, 140 (46.51%) had positive antibody responses for TBIs from an ELISA (enzyme-linked immunoassay) that was based on a modified two-tiered testing protocol. A total of 93 (66.43%) patients had positive antibody responses to one TBI: 83 (59.29%) for Borrelia, 7 (5.00%) for Rickettsia, and 1 (0.71%) each for either Babesia, Bartonella, or Ehrlichia. The remaining 47 (33.57%) patients were infected with multiple TBIs. These patients were treated with combination antibiotics and monitored at two subsequent follow-ups. Only 2 of 101 patients (1.98%) had discontinued treatment by the second follow-up. In the first follow-up with 118 patients, 70 (59.32%) reported pain and 48 (40.68%) had neurological symptoms. In the next follow-up of 101 patients, 41 (40.59%) had pain while 30 (29.70%) had neurological symptoms. There were statistically significant reductions in the incidence of pain (41.43%) and neurological (37.50%) symptoms between follow-ups. Thus, our study demonstrates that combination antibiotics effectively relieve TBI symptoms with good patient tolerance.
摘要：
蜱传感染（TBI）的患病率上升需要进一步关注。这项研究回顾性调查了TBIs的类型，症状,如果联合抗生素对爱尔兰一家传染病诊所的患者队列有帮助。在这张图表中，对301个人(184名女性，117名男性)进行了TBIs测试，140(46.51%)对来自ELISA(酶联免疫测定法)的TBI具有阳性抗体应答,所述ELISA基于修改的两级测试方案。共有93例（66.43％）患者对一种TBI有阳性抗体反应：疏螺旋体属83例（59.29％），立克次体为7（5.00%），和1个(0.71%)的巴贝西亚，巴尔通体,或者Ehrlichia.其余47例（33.57％）患者感染了多个TBI。这些患者接受联合抗生素治疗，并在随后的两次随访中进行监测。101例患者中只有2例（1.98％）在第二次随访时停止了治疗。在对118名患者的首次随访中，70例（59.32%）出现疼痛，48例（40.68%）出现神经系统症状。在接下来的101名患者的随访中，41（40.59％）有疼痛，而30（29.70％）有神经系统症状。随访期间疼痛(41.43%)和神经症状(37.50%)的发生率有统计学意义的降低。因此，我们的研究表明,联合应用抗生素可有效缓解TBI症状,患者耐受性良好.
