PDF(Pubmed)
Abstract：
Prostate cancer is one of the most common tumors among the male population. Magnetic resonance imaging (MRI), standardized by the PI-RADS version 2.1 scoring system, has a fundamental role in detecting prostate cancer and evaluating its aggressiveness. Diffusion-weighted imaging sequences and apparent diffusion coefficient values, in particular, are considered fundamental for the detection and characterization of lesions. In 2016 the International Society of Urological Pathology introduced a new anatomopathological 5-grade scoring system for prostate cancer. The aim of this study is to evaluate the correlation between quantitative apparent diffusion coefficient values (ADC) derived from diffusion-weighted imaging (DWI) sequences and the International Society of Urological Pathology (ISUP) and PI-RADS groups. Our retrospective study included 143 patients with 154 suspicious lesions, observed on prostate magnetic resonance imaging and compared with the histological results of the biopsy. We observed that ADC values can aid in discriminating between not clinically significant (ISUP 1) and clinically significant (ISUP 2-5) prostate cancers. In fact, ADC values were lower in ISUP 5 lesions than in negative lesions. We also found a correlation between ADC values and PI-RADS groups; we noted lower ADC values in the PI-RADS 5 and PI-RADS 4 groups than in the PI-RADS 3 group. In conclusion, quantitative apparent diffusion coefficient values can be useful to assess the aggressiveness of prostate cancer.
摘要：
前列腺癌是男性人群中最常见的肿瘤之一。磁共振成像(MRI),由PI-RADS2.1版评分系统标准化，在检测前列腺癌和评估其侵袭性方面具有重要作用。扩散加权成像序列和表观扩散系数值，特别是,被认为是检测和表征病变的基础。2016年，国际泌尿外科病理学会推出了一种新的前列腺癌解剖病理学5级评分系统。这项研究的目的是评估从扩散加权成像（DWI）序列得出的定量表观扩散系数值（ADC）与国际泌尿外科病理学会（ISUP）和PI-RADS组之间的相关性。我们的回顾性研究包括143例患者，154个可疑病变，在前列腺磁共振成像上观察，并与活检的组织学结果进行比较。我们观察到ADC值可以帮助区分非临床显著(ISUP1)和临床显著(ISUP2-5)前列腺癌。事实上,ISUP5病变的ADC值低于阴性病变。我们还发现ADC值与PI-RADS组之间存在相关性；我们注意到PI-RADS5和PI-RADS4组的ADC值低于PI-RADS3组。总之,定量表观扩散系数值可用于评估前列腺癌的侵袭性。
