PDF(Pubmed)
Abstract：
Matricellular proteins are secreted extracellular proteins that bear no primary structural functions but play crucial roles in tissue remodeling during development, homeostasis, and aging. Despite their low expression after birth, matricellular proteins within skin compartments support the structural function of many extracellular matrix proteins, such as collagens. In this review, we summarize the function of matricellular proteins in skin stem cell niches that influence stem cells\' fate and self-renewal ability. In the epidermal stem cell niche, fibulin 7 promotes epidermal stem cells\' heterogeneity and fitness into old age, and the transforming growth factor-β-induced protein ig-h3 (TGFBI)-enhances epidermal stem cell growth and wound healing. In the hair follicle stem cell niche, matricellular proteins such as periostin, tenascin C, SPARC, fibulin 1, CCN2, and R-Spondin 2 and 3 modulate stem cell activity during the hair cycle and may stabilize arrector pili muscle attachment to the hair follicle during piloerections (goosebumps). In skin wound healing, matricellular proteins are upregulated, and their functions have been examined in various gain-and-loss-of-function studies. However, much remains unknown concerning whether these proteins modulate skin stem cell behavior, plasticity, or cell-cell communications during wound healing and aging, leaving a new avenue for future studies.
摘要：
基质细胞蛋白是分泌的细胞外蛋白，不具有主要结构功能，但在发育过程中在组织重塑中起关键作用。稳态，和衰老。尽管他们出生后的表情很低，皮肤区室中的基质细胞蛋白支持许多细胞外基质蛋白的结构功能，如胶原蛋白。在这次审查中,我们总结了基质细胞蛋白在皮肤干细胞生态位中影响干细胞命运和自我更新能力的功能。在表皮干细胞小生境中，腓骨蛋白7促进表皮干细胞的异质性和适应老年，和转化生长因子-β-诱导蛋白ig-h3（TGFBI）-促进表皮干细胞生长和伤口愈合。在毛囊干细胞小生境中，基质细胞蛋白，如骨膜素，生腱C,SPARC,腓骨蛋白1，CCN2和R-Spondin2和3调节毛发周期中的干细胞活性，并可能在毛发勃起（鸡皮疙瘩）期间稳定毛囊的毛囊肌附着。在皮肤伤口愈合，体细胞蛋白上调，它们的功能已经在各种功能的得失研究中得到了检验。然而,关于这些蛋白质是否能调节皮肤干细胞的行为，可塑性,或在伤口愈合和老化过程中的细胞-细胞通信，为未来的研究留下了新的途径。
