PDF(Pubmed)
Abstract：
As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They are in high demand because of their many health benefits. However, their low bioavailability makes them complex compounds to use for therapeutic purposes. Due to the limited solubility of phytocompounds, dietary supplements made from them may only be partially effective. Such molecules include fisetin, found in strawberries, and have shown great promise in treating Alzheimer\'s disease and cancer. Unfortunately, because of their limited water solubility, low absorption, and poor bioavailability, the assistance of nanotechnology is required to allow them to fulfil their potential fully. Here, we provide evidence that nanodelivery methods and structure modifications can improve fisetin bioavailability, which is linked to improvements in therapeutic efficacy. An open question remains as to which nanocarrier should be chosen to meet the abovementioned requirements and be able to enhance fisetin\'s therapeutic potential to treat a particular disease.
摘要：
作为次生植物代谢产物，多酚在水果和蔬菜中含量丰富。它们的需求量很大，因为它们具有许多健康益处。然而,它们的低生物利用度使它们复杂的化合物用于治疗目的。由于植物化合物的溶解度有限，用它们制成的膳食补充剂可能只是部分有效。这样的分子包括非瑟酮，在草莓中发现，并在治疗阿尔茨海默病和癌症方面显示出巨大的希望。不幸的是,由于它们有限的水溶性，低吸收,生物利用度差,需要纳米技术的帮助才能使他们充分发挥潜力。这里,我们提供了纳米递送方法和结构修饰可以提高非塞素生物利用度的证据，这与治疗效果的改善有关。关于应选择哪种纳米载体以满足上述要求并能够增强非瑟酮治疗特定疾病的治疗潜力，仍然存在一个悬而未决的问题。
