PDF(Pubmed)
Abstract：
Zbtb20 (zinc finger and BTB domain-containing protein 20) is a transcription factor with a zinc finger DNA binding domain and a BTB domain responsible for protein-protein interaction. Recently, this TF has received attention because new data showed its pivotal involvement in normal neural development and its regulatory effects on proliferation and differentiation in different tissues. Zbtb20 was shown to increase proliferation and migration and confer resistance to apoptosis in the contexts of many malignant tumors like hepatocellular carcinoma, non-small-cell lung carcinoma, gastric adenocarcinoma, glioblastoma multiforme, breast cancer, and acute myeloid leukemia. The involvement of Zbtb20 in tumor biology is best studied in hepatocellular carcinoma, where it is a promising candidate as an immunohistochemical tumor marker or may be used in patient screening. Here we review the current data connecting Zbtb20 with malignant tumors.
摘要：
Zbtb20(含锌指和BTB结构域的蛋白质20)是具有锌指DNA结合结构域和负责蛋白质-蛋白质相互作用的BTB结构域的转录因子。最近,这种TF受到了关注，因为新数据显示其在正常神经发育中的关键参与及其对不同组织增殖和分化的调节作用。在许多恶性肿瘤如肝细胞癌的背景下，Zbtb20被证明可以增加增殖和迁移，并赋予细胞凋亡抗性。非小细胞肺癌,胃腺癌,多形性胶质母细胞瘤，乳腺癌,和急性髓细胞性白血病.Zbtb20在肿瘤生物学中的参与最好的研究是在肝细胞癌中，其中它是一个有希望的候选作为免疫组织化学肿瘤标志物或可用于患者筛查。在这里，我们回顾了将Zbtb20与恶性肿瘤联系起来的最新数据。
