PDF(Pubmed)
Abstract：
This real-world analysis investigated the characteristics and treatment patterns of patients with hereditary angioedema (HAE) in Italy using the administrative data of health units across Italy. Patients were identified via exemption code or HAE-specific treatments (thus, all known forms, type I, II and, III, were included). The index date was that of first prescription of HAE treatments within the inclusion period (01/2010-06/2021) or of the date of exemption. The number of HAE patients included was 148 (43.2% male, mean age 43.3 years). Gastrointestinal disorders affected 36.5% patients, hypertension affected 28.4%, hypercholesterolemia affected 11.5%, and depression affected 9.5%. The frequent gastrointestinal involvement was further confirmed by the use of antiemetics and systemic antihistamines that doubled after the index date. Among patients enrolled by treatment (n = 125), n = 105 (84%) were receiving a treatment for acute attacks. This analysis provided insights into the characterization of patients with HAE and their management in Italian clinical practice, suggesting that an unmet therapeutic need could be present for such patients in terms of the clinical burden.
摘要：
这项真实世界的分析使用意大利各地卫生部门的管理数据，调查了意大利遗传性血管性水肿（HAE）患者的特征和治疗模式。通过豁免代码或HAE特异性治疗确定患者(因此，所有已知的形式，I型,II和,III,包括在内）。索引日期是纳入期内（01/2010-06/2021）或豁免日期的第一个HAE治疗处方。纳入的HAE患者为148例(43.2%为男性,平均年龄43.3岁)。胃肠道疾病影响36.5％的患者，高血压影响28.4%，高胆固醇血症影响11.5%，抑郁症影响了9.5%。止吐药和全身性抗组胺药的使用在索引日期后翻了一番，进一步证实了频繁的胃肠道受累。在接受治疗的患者中（n=125），n=105（84％）正在接受急性发作的治疗。该分析提供了有关HAE患者的特征及其在意大利临床实践中的管理的见解，这表明，就临床负担而言，此类患者可能存在未满足的治疗需求。
