PDF(Pubmed)
Abstract：
Oligella ureolytica is a Gram-negative bacillus, a member of the Alcaligenaceae family, that had never previously been reported as lethal. Herein, a case of fatal infection caused by Oligella ureolytica in an elderly woman with suspected bladder cancer is reported. The species identification was confirmed through Sanger sequencing of the bacterial 16S rRNA sequence and compared to published sequences for phylogenetic analysis. Initial antibiotic therapy with ceftriaxone and oxacillin was initiated but had to be switched due to resistance. Cefepime in combination with metronidazole was administered, unfortunately failing to prevent the patient\'s death. Further studies are needed to explore additional factors influencing clinical outcomes in Oligella ureolytica infections.
摘要：
解脲大肠杆菌是一种革兰氏阴性杆菌，alcaligenaceae家族的成员，以前从未被报道为致命的。在这里，据报道，一名怀疑患有膀胱癌的老年妇女中，由溶尿Oligella引起的致命感染病例。通过细菌16SrRNA序列的Sanger测序确认了物种鉴定，并将其与已发表的序列进行系统发育分析。开始使用头孢曲松和苯唑西林的初始抗生素治疗，但由于耐药性而不得不转换。头孢吡肟联合甲硝唑给药，不幸的是未能阻止病人的死亡。需要进一步的研究来探索影响溶尿Oligella感染临床结局的其他因素。
