PDF(Pubmed)
Abstract：
The eyes provide themselves with immune tolerance. Frequent skin inflammatory diseases in young blind people suggest, nonetheless, that the eyes instruct a systemic immune tolerance that benefits the whole body. We tested this premise by using delayed skin contact hypersensitivity (DSCH) as a tool to compare the inflammatory response developed by sighted (S) and birth-enucleated (BE) mice against oxazolone or dinitrofluorobenzene at the ages of 10, 30 and 60 days of life. Adult mice enucleated (AE) at 60 days of age were also assessed when they reached 120 days of life. BE mice displayed exacerbated DSCH at 60 but not at 10 or 30 days of age. AE mice, in contrast, show no exacerbated DSCH. Skin inflammation in 60-day-old BE mice was hapten exclusive and supported by distinct CD8+ lymphocytes. The number of intraepidermal T lymphocytes and migrating Langerhans cells was, however, similar between S and BE mice by the age of 60 days. Our observations support the idea that the eyes instruct systemic immune tolerance that benefits organs outside the eyes from an early age. The higher prevalence of inflammatory skin disorders reported in young people might then reflect reduced immune tolerance associated with the impaired functional morphology of the eyes.
摘要：
眼睛为自己提供免疫耐受。年轻盲人常见的皮肤炎症性疾病建议，尽管如此,眼睛指示对全身有益的全身免疫耐受。我们通过使用迟发性皮肤接触超敏反应（DSCH）作为工具来比较视力（S）和出生去核（BE）小鼠在10、30和60天的年龄对恶唑酮或二硝基氟苯的炎症反应来测试这一前提。当它们达到120天的生命时,还评估在60日龄时摘除(AE)的成年小鼠。BE小鼠在60日龄时表现出恶化的DSCH,但在10或30日龄时没有。AE小鼠，相比之下,显示没有恶化的DSCH。60天大的BE小鼠的皮肤炎症是半抗原专有的，并由不同的CD8淋巴细胞支持。表皮内T淋巴细胞和迁移朗格汉斯细胞的数量是，然而,S和BE小鼠在60日龄时相似。我们的观察结果支持这样的观点，即眼睛指示从早期起就有益于眼睛外部器官的全身免疫耐受。年轻人中报道的炎症性皮肤病的患病率较高，则可能反映出与眼睛功能形态受损相关的免疫耐受降低。
